Computational NeuroscienceBistable behaviour in a neocortical neurone modelDelord, Bruno1; Klaassen, Arno J.1,2; Burnod, Yves1; Costalat, Robert1; Guigon, Emmanuel1,3,4Author Information 1INSERM CREARE, UPMC, Boite 23, 9, quai Saint-Bernard, 75005 Paris 2LIMSI-CNRS, B.P. 133, 91403 Orsay Cedex 3CNRS URA 1488, Institut des Neurosciences, 9, quai Saint-Bernard, 75005 Paris, France. 1,4Corresponding Author and Address: Emmanuel Guigon ACKNOWLEDGEMENTS: We thank J. Hirsch, C. Hammond, B. Hamon, F. Crépel, J. Burger, H.C. Tuckwell, L. Borg-Graham for fruitful discussions, and O. Parkes for editing the English text. Received 28 November 1996; accepted 5 December 1996 NeuroReport: March 3, 1997 - Volume 8 - Issue 4 - p 1019-1023 Buy Abstract INTRACELLULAR recordings have shown that neocortical pyramidal neurones have an intrinsic capacity for regenerative firing. The cellular mechanism of this firing was investigated by computer simulations of a model neurone endowed with standard action potential and persistent sodium (gNaP) conductances. The firing mode of the neurone was determined as a function of leakage and NaP maximal conductances (g̱l and g̱NaP). The neurone had two stable states of activity (bistable) over wide range of g̱l and g̱NaP, one at the resting potential and the other in a regenerative firing mode, that could be triggered by a transient input. This model points to a cellular mechanism that may contribute to the generation and maintenance of long-lasting sustained neuronal discharges in the cerebral cortex. © Lippincott-Raven Publishers.