NeurochemistryD1–D2 dopamine receptor interaction: an in vivo single unit electrophysiological studyMurer, M Gustavo1; Riquelme, Luis A.1; Tseng, Kuei Y.1; Cristal, Adrian2; Santos, Juan2; Pazo, Jorge H.1,3Author Information 1Laboratorio de Neurofisiología, Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad de Buenos Aires; Paraguay 2155, Buenos Aires 1121 2GIREN, Facultad de Ciencias de la Computación, Universidad de Buenos Aires, Argentina 3Corresponding Author: Jorge H. Pazo ACKNOWLEDGEMENTS: This study was supported by grants from CONICET and Fundación Antorchas of Argentina. Received 29 November 1996; accepted 5 December 1996 NeuroReport: February 10th, 1997 - Volume 8 - Issue 3 - p 783-787 Buy Abstract AFTER intrastriatal administration of selective dopamine receptor agonists only a small percentage of substantia nigra pars reticulata single units showed changes in firing rate (23% after SKF38393 and 17% after quinpirole). After their intrastriatal co-administration, however, or after the application of the non-selective dopamine receptor agonist apomorphine, 72% and 69% of units responded, respectively. This result confirms the participation of the striatum in the phenomenon of D1–D2 receptor interaction, and show that co-activation of both receptor subtypes produced a maximal effect on basal ganglia output nuclei. © Lippincott-Raven Publishers.