Neuropharmacology and NeurotoxicologyInherited, selective hyporesponsiveness to the analgesic action of nicotine in miceSeale, Thomas W.1,2,4; Nael, Raha1; Basmadjian, Garo3Author Information 1Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA 2Department of Psychiatry and Behavioral Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA 3Department of Medicinal Chemistry and Therapeutics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA 4Corresponding Author and Address: Thomas W. Seale, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA ACKNOWLEDGEMENTS: This study was supported in part by the National Institute on Drug Abuse (DA08587) and the Oklahoma Board of Higher Regents Summer Academy. R.N. was a fellow of the Summer Academy and a senior student at the Oklahoma School of Science and Mathematics. Received 16 August 1996; accepted 11 September 1996 NeuroReport: December 20, 1996 - Volume 8 - Issue 1 - p 191-195 Buy Abstract THE acute dose-dependent analgesic activity of nicotine, as measured by the tail-flick assay, differed significantly between CD-1 and CF-1 outbred strains of mice. Differing responsiveness to the tail-flick stimulus did not explain this pharmacological effect. The inherent analgesic hyporesponsiveness of CF-1 mice was pharmacologically selective. Xilocaine and morphine produced an analgesic response of large magnitude in CF-1 mice. Reduced efficacy of nicotine in the CF-1 analgesia assay was not observed in its action on locomotor activity or in the induction of seizures and lethality. These findings have practical significance in identifying the importance of genotype in choice of strain for preclinical pharmacological studies of nicotine-induced analgesia and indicate that genetic analysis may provide a valuable tool for investigating the mechanism underlying the analgesic action of nicotine. © Lippincott-Raven Publishers.