Article: PDF OnlyEvidence for cholecystokininA receptors in bovine adrenal chromaffin cellsAarnisalo, Antti M.; Vainio, Petri J.; Männistö, Pekka T.; Vasar, Eero; Tuominen, Raimo K.Author Information Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O.Box 8, SF-00014 University of Helsinki, Finland; Department of Medical Pharmacology, University of Uppsala, Uppsala, Sweden; Department of Physiology, University of Tartu, Tartu, Estonia NeuroReport: September 2, 1996 - Volume 7 - Issue 13 - p 2167-2170 Buy Abstract We have studied a possible role of cholecystokinin (CCK) in regulating adrenal medullary function. Caerulein (10−10-10−7 M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine adrenal medullary (BAM) chromaffin cells in a concentration-dependent manner. The effect of caerulein was antagonized by devazepide, a selective CCKA-receptor antagonist, but not by L-365.260, a selective CCKB-receptor antagonist. These results suggest that BAM cells possess functional CCK receptors of the CCKA-subtype. Stimulation of these receptors with caerulein activates a signal transduction pathway via phospholipase C. CCK may regulate catecholamine release in BAM cells. © Lippincott-Raven Publishers.