Motivation, Emotion, Feeding, Drinking, Sexual Behaviour: PDF OnlyInhibition of nitric oxide synthase causes anxiolytic-like behaviour in an elevated plus-mazeVolke, Vallo; Kõks, Sulev; Vasar, Eero; Bourin, Michel; Bradwejn, Jacques; Männistö, Pekka T.Author Information Institute of Physiology, Tartu University, 2 Näituse Street, EE-2400 Tartu, Estonia; 1Laboratory of Pharmacology, University of Nantes, 1 Rue Gaston Veil, 44035 Nantes Cedex, France; 2Clarke Institute of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada; 3Department of Medical Pharmacology, University of Uppsala, P.O. Box 593, S-75124, Uppsala, Sweden NeuroReport: July 1995 - Volume 6 - Issue 10 - p 1413-1416 Buy Abstract THE action of inhibition of nitric oxide (NO) synthase by NG-nitro-L-arginine methyl ester (L-NAME) (1–20 mg kg-1) on the exploratory behaviour of rats in the elevated plus-maze was studied. L-NAME induced an anxiolytic-like effect in the plus-maze test, showing a reverse U-shape action behaviour, with a maximal effect at 10 mg kg-1. This effect was not related to a non-specific increase in motor activity, since in the open field test L-NAME did not affect locomotor activity of rats. Pretreatment of rats with L-NAME (1–10 mg kg-1) also tended to attenuate the anti-exploratory action of CCK agonist caerulein (5 mUg kg-1), but this action was not significant. In conclusion, it appears that NO may be involved in the process that can lead to anxiety in the rat. © Lippincott-Raven Publishers.