Clinical Neuroscience and Neuropathology: PDF OnlyCorrelation between food intake and CSF IL-1α in anorectic tumor bearing ratsOpara, Elizabeth I.; Laviano, Alessandro; Meguid, Michael M.; Yang, Zhong-jin Author Information Surgical Metabolism and Nutrition Laboratory Department of Surgery SUNY Health Science Center, 750 East Adams Street, Syracuse, NY 13210, USA NeuroReport: March 27, 1995 - Volume 6 - Issue 5 - p 750-752 Buy Abstract POSTULATING that central IL-1 is involved in the pathogenesis of cancer anorexia we measured IL-1α in cerebrospinal fluid (CSF) from anorectic tumor bearing (TB) rats and non-tumor bearing controls, and correlated their CSF IL-1α with food intake and tumor weight. Food intake in controls was significantly higher than that in anorectic TB rats. Eight of the 13 anorectic TB rats had detectable CSF IL-1α; no CSF IL-1α was detected in controls. In anorectic TB rats a negative correlation existed between CSF IL-1α and food intake and a positive correlation between CSF IL-1α and tumor weight. Data suggest a link between CSF IL-1α and the pathogenesis of cancer anorexia. © 1995 Wolters Kluwer Health | Lippincott Williams & Wilkins
