Neuropharmacology and Neurotoxicology: PDF OnlyNigral dopaminergic cell loss in vitamin E deficient ratsDexter, David T.; Nanayakkara, Ishanthi; Goss-Sampson, Mark A.1; Muller, David P. R.1; Harding, Anita E.2; Marsden, C. David2; Jenner, PeterAuthor Information Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, Manresa Road, London SW3 6LX; 1 Division of Biochemistry and Genetics, Institute of Child Health, London; and 2University Department of Clinical Neurology, Institute of Neurology, London, UK NeuroReport: September 8, 1994 - Volume 5 - Issue 14 - p 1773-1776 Buy Abstract α-Tocopherol concentrations in brain were reduced to 3% of control levels in rats fed a vitamin E deficient diet for 52 weeks. Vitamin E deficiency resulted in a 19–33% loss of tyrosine hydroxylase (TH) immunopositive neurones in the substantia nigra, but not in the adjacent ventral tegmental area, compared with controls. Vitamin E deficiency, however, did not reduce striatal dopamine concentrations or turnover. When antioxidant defence mechanisms are defective, as in chronic vitamin E deficiency, the nigrostriatal pathway may be affected by oxidative damage and this may have implications for Parkinson's disease. © Lippincott-Raven Publishers.