Developmental Neuroscience: PDF OnlyAcetylcholine receptor and myogenic factor gene expression in Torpedo embryonic developmentAsher, Orna1; Fuchs, Sara1; Souroujon, Miriam C.1,2 Author Information 1Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel 2The Open University of Israel, Tel Aviv 61392, Israel NeuroReport: August 15, 1994 - Volume 5 - Issue 13 - p 1581-1584 Buy Abstract THE mRNA levels of acetylcholine receptor (AChR) and myogenic factors were followed during embryonic development of Torpedo skeletal muscle and its homologue, the electric organ. A different developmental pattern of AChR gene expression was found in these two tissues: a slight decrease in the muscle, and a marked increase, concomitant with synapse formation, in the electric organ. However, the developmental pattern of MyoD and MRF4 mRNA levels was similar in both tissues, with no significant changes during development. This is in contrast with the sharp increase in the expression of AChR in the electric organ and may suggest that the burst in the expression of AChR during the differentiation of myotubes into electrocytes is not regulated by changes in the myogenic factor mRNA levels. © Lippincott-Raven Publishers.
