ORIGINAL ARTICLE: PDF OnlyReduced transferrin binding in Down syndrome a route to senile plaque formation and dementiaHodgkins, Paul S.1; Prasher, Vee2; Farrar, Gill3; Armstrong, Richard4; Sturman, Steven5; Corbett, John2; Blair, John A.6,CAAuthor Information 1MRC Radiobiology Unit, Chilton, Didcot 2Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham 3Roche Products Ltd, Welwyn Garden City 4Vision Sciences, Aston University, Birmingham 5University Department for Neurology, Queen Elizabeth Hospital, Birmingham 6Pharmaceutical Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK NeuroReport: October 1993 - Volume 5 - Issue 1 - p 21-24 Buy Abstract PLASMA transferrin binding in Down syndrome and Alzheimer's disease is significantly reduced compared with age matched controls and it was thought this may help elucidate a pathological time sequence for the onset of dementia in Down syndrome. In Down syndrome, there was a reduction in gallium and aluminium transferrin binding both with age and the onset of dementia. Non-transferrin bound gallium species were identified as non-transportable phosphate or silicate. Thus, the route of entry of metals into the brain must be via a transferrin mediated complex only. A clear sequence of pathological events has been demonstrated in Down syndrome which shows the pathway to development of plaques and dementia and this is believed to have an immunological origin. © Lippincott-Raven Publishers.