Neuropharmacology and Neurotoxicology: PDF OnlyTrkA NGF receptor expression by non-cholinergic thalamic neuronsVenero, Jose L.; Hefti, Franz Author Information Division of Neurogenerontology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA NeuroReport: July 1993 - Volume 4 - Issue 7 - p 959-962 Buy Abstract EXPRESSION of the trkA receptor for nerve growth factor was analyzed by mRNA in situ hybridization in the telen-cephalon and diencephalon in adult rats. Two densely packed populations expressing trkA. mRNA were detected in the thalamus, in the paraventricular thalamic nucleus anterior and reuniens thalamic nucleus. These neurons did not express mRNA coding for choline acetyltrans-ferase. In basal forebrain and striatum, trkA. and choline acetyltransferase mRNAs showed identical patterns of expression, supporting the view that trkA expression is confined to cholinergic population in these areas. In contrast, cholinergic neurons of the medial habenula did not express trkA mRNA. Our findings suggest the existence of previously undiscovered populations of non-cholinergic, NGF responsive populations in the thalamis. © Lippincott-Raven Publishers.