Neuropharmacology and Neurotoxicology: PDF OnlyThe effects of orally active enkephalinase inhibitors on morphine withdrawal syndromeDzoljic, Mihailo R.; Bokszanska, Agness; Korenhof, Annemiek M.; Kaplan, Charles D.; Dzoljic, Misa1; Rupreht, Jose1; Zijlstra, Freek J.; Brinkman, Edwin C.A.; Cappendijk, Susan L.T.2Author Information Department of Pharmacology 1Anaesthesiology and 2Addiction Research Institute, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands NeuroReport: July 1992 - Volume 3 - Issue 7 - p 637-640 Buy Abstract Considerable evidence has accumulated to suggest that intracerebroventricular administration of enkephalinase inhibitors, which do not penetrate the blood-brain barrier, significantly attenuates opioid withdrawal syndrome. Therefore, the aim of this study was to examine the effect of intraperitoneal (i.p.) administration of orally active enkephalinase inhibitors, acetorphan (2.5–20 mg kg-1) and SCH 34826 (15–120 mg kg-1). These drugs significantly decreased the severity of the naloxone precipitated withdrawal syndrome in morphine dependent rats and mice. It therefore appears that these orally active enkephalinase inhibitors are promising tools in studying modulation of opioid dependence phenomena. © Lippincott-Raven Publishers.