Neuropharmacology and Neurotoxicology: PDF OnlyVitamin E supplements fail to protect mice from acute MPTP neurotoxicityGong, Li1; Daigneault, Ernest A.1; Acuff, Robert V.2; Kostrzewa, Richard M.1Author Information 1Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA 2Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA NeuroReport: September 1991 - Volume 2 - Issue 9 - p 544 Buy Abstract THE effect of chronic treatment with vitamin E (VE) on acute l-methyl-4-phenyl-l, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity, as assessed by striatal dopamine (DA) depletion, was studied. Male C57B1/6J mice were fed VE (48 mg kg−1 per day, intragastric) for 4, 8, or 12 weeks prior to administration of MPTP (20 mg kg−1, i.p. × 3, 2 h intervals) or its diluent. Brain VE concentration was increased by exogenous supplements for 12 weeks. Striatal DA content was reduced by 85% to 90% after MPTP in control and VE-treated mice. Mice with elevated cerebral VE were not protected from MPTP toxicity, with DA content as an indicator. In conclusion, these findings indicate that moderate elevation of brain VE is not adequate for protecting DA-containing neurons against the toxic actions of a high dose of MPTP. © Lippincott-Raven Publishers.