Regeneration and Transplantation: PDF OnlyEffects of mianserin and fluoxetine on axonal regeneration of brain catecholamine neuronsNakamura, ShojiAuthor Information Department of Physiology, Faculty of Medicine, Kanazawa University, Kanazawa 920, Japan NeuroReport: September 1991 - Volume 2 - Issue 9 - p 525-528 Buy Abstract THE antidepressants, mianserin (MIA) and fluoxetine (FLU), were examined to see if they could induce regeneration of catecholaminergic axons in the rat cerebral cortex. MIA, which has a small or no effect in noradrenaline (NA) reuptake but may enhance release by blocking presynaptic inhibition mediated by α2-adrenoceptors, induced regeneration of catecholamine fibers. In contrast, FLU, a potent reuptake blocker of serotonin was ineffective. This finding suggests that the antidepressant-induced regeneration of cortical catecholamine fibers is associated, at least in part, with enhanced noradrenergic transmission. © Lippincott-Raven Publishers.