Neurochemistry: PDF OnlyNucleus basalis lesions decrease α-and α-bungarotoxins binding in rat cortexSugaya, Kiminobu1,; Downen, Martha*, 2; Giacobini, Ezio2Author Information 1Research Inst. for Biosciences, Science University of Tokyo, 2669 Yamazaki, Noda City, Chiba 278, Japan 2Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794–9230, USA *Present Address: Dept. Pharmacological and Physiological Sciences, University of Chicago, 947 East 58th, Box 271, Chicago, IL 60637, USA NeuroReport: April 1991 - Volume 2 - Issue 4 - p 177-180 Buy Abstract A unilateral ibotenic acid lesion of the nucleus basalis magnocellularis in the rat, which is known to produce a reduction in cortical choline acetyltransferase activity and acetylcholine release, produces a decrease of 125I-alpha-bungarotoxin and 125I-kappa-bungarotoxin binding sites in the frontoparietal cortex of the lesioned hemisphere. This decrease can be observed at two weeks following the lesion and persists for up to twelve weeks. The results suggest that a population of bungarotoxin binding sites may have a presynaptic localization. © Lippincott-Raven Publishers.