Learning and Memory: PDF OnlyMorphological correlates of persistent potentiation in the chick brain sliceBradley, Philip M.; Burns, Ben Delisle; Titmuss, John; Webb, Alison C.Author Information Division of Neurobiology, Medical School, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, NE2 4HH, UK. NeuroReport: April 1991 - Volume 2 - Issue 4 - p 197-200 Buy Abstract IN an in-vitro slice preparation of the chick brain it is possible to induce persistent potentiation of responses to single electrical stimuli by giving two bursts of 300 stimuli at 5 Hz separated by ten minutes of control stimulation at 0.1 Hz. We investigated the morphological correlates of this potentiation in a group of 2 day old chicks using quantitative electron microscopical techniques. It was found that in slices which showed a clearly potentiated response there was a significant increase in the size of the postsynaptic densities of synapses on spines in the left hyperstriatum ventrale (IMHV). No such increases were seen in a control group nor in slices which failed to potentiate. These results provide further evidence for the lability of synapses in the IMHV. © Lippincott-Raven Publishers.