Neurophysiology, Basic and Clinical: PDF OnlyLandau-Kleffner syndrome epileptic activity in the auditory cortexPaetau, Ritva; Kajola, Matti; Korkman, Marit1; Hämäläinen, Matti; Granström, Marja-Liisa1; Hari, RiittaAuthor Information Low Temperature Laboratory, Helsinki University of Technology, 02150 Espoo, Finland 1Helsinki University Clinic of Child Neurology, Children's Castle Hospital, Helsinki, Finland NeuroReport: April 1991 - Volume 2 - Issue 4 - p 201-204 Buy Abstract THE Landau-Kleffner syndrome (LKS) is characterized by electroencephalographic spike discharges and verbal auditory agnosia in previously healthy children. We recorded magnetoencephalographic (MEG) spikes in a patient with LKS, and compared their sources with anatomical information from magnetic resonance imaging. All spikes originated close to the left auditory cortex. The evoked responses were contaminated by spikes in the left auditory area and suppressed in the right — the latter responses recovered when the spikes disappeared. We suggest that unilateral discharges at or near the auditory cortex disrupt auditory discrimination in the affected hemisphere, and lead to suppression of auditory information from the opposite hemisphere, thereby accounting for the two main criteria of LKS. © Lippincott-Raven Publishers.