Neurophysiology, basic and clinical: PDF OnlyGioanni Yves; Goyon, Didier; Prevost, JanineNeuroReport: January 1991 - p 46-52 Buy Abstract THE effects of intracerebroventricular administration of dermorphin (μ agonist) and dermenkephalin ( agonist) were studied at the electrocorticographic (ECoG) and electromyographic (EMG) levels in free-moving rats. A very low dose of dermorphin (125 pmol) induced ECoG spiking, occasional myoclonic jerks, wet-dog shakes and catalepsy. In addition, electrical seizures were triggered with doses of 250 to 500 pmol. These signs were reversed by an i.p. injection of naloxone (1 mg kg-1). However, no epileptic-like phenomena were seen after administration of dermenkephalin up to 1 nmol. These results indicate that μ but not receptors are involved in the epileptogenic effect of intraventricularly administered opiates. © Lippincott-Raven Publishers.