Developmental Neuroscience: PDF OnlyEthanol inhibits NMDA-stimulated neurite growth by sensory neurons in vitroDow, K. E.*; Riopellet, R. J.† Author Information *Departments of Pediatrics, Queens University, Apps Research Centre, Kingston General Hospital, Kingston, Ontario, Canada K7L 2V7 †Departments of Medicine, Queens University, Apps Research Centre, Kingston General Hospital, Kingston, Ontario, Canada K7L 2V7 NeuroReport: October 1990 - Volume 1 - Issue 2 - p 111-114 Buy Abstract N-METHYL-D-ASPARATE (NMDA) produced dose dependent neurite growth from 8 day chick embryo sensory neurons in-vitro on a laminin substrate. NMDA-stimu-lated neurite growth was blocked by the competitive antagonist D-2-amino-5-phosphonovaleric acid (APV), by an antagonist of the glycine modulatory site kyn-urenate, and by the NMDA ion channel antagonist Mg2+. Ethanol blocked the NMDA-mediated neurotrophic effect in a manner that was additive with the effects of Mg2+, but non-additive with the inhibitory influences of APV and kynurenate. Thus the influences of ethanol were mediated at the NMDA receptor/modulatory site. These observations have implications for the understanding of adverse influences of ethanol on neuronal development and connectivity and on activity-dependent enduring changes in synaptic changes in synaptic function. © Lippincott-Raven Publishers.