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Relation between afamin level and some inflammatory markers in obese children

Ahmed, Hanaa H.a; Abdel Hameed, Enas R.b; Shehata, Manal A.b; El Wakeel, Maged A.b; Elsawy, Dina H.c; Elshafie, Amal I.d

doi: 10.1097/01.MJX.0000464329.16129.c0

Objective The aim of this study was to evaluate the status of inflammatory markers and adipokines in obese children and their correlations with serum concentrations of afamin, a novel vitamin E-binding protein, which was presumed to play a possible role in the development of obesity.

Participants and methods It was a case–control study. Eighty children were recruited for the study (40 nonobese and 40 obese). Height, weight, BMI, and BMI Z-score were estimated. Serum concentration of high-sensitive C-reactive protein (hsCRP), adiponectin, and afamin were measured and correlated with the anthropometric measurements.

Results Mean serum levels of afamin and CRP were significantly elevated in obese children compared with controls (P<0.01). There was a highly significant positive correlation between afamin and BMI Z-score (r=0.41, P=0.008), and a negative correlation between afamin and adiponectin were recorded (r=−0.32, P=0.048), whereas there was a nonsignificant association between afamin and hsCRP.

Conclusion The current study highlighted that obese children had higher levels of afamin and CRP than nonobese children. However, further studies are necessary to elucidate the action of afamin and its association with other inflammatory markers that may lead to the identification of new roles of this marker in the search of new therapeutics for this epidemic disease.

Departments of aHormone

bChild Health, National Research Centre

cDepartment of Pediatrics, Research Institute of Ophthalmology

dDepartment of Health Radiation Research, National Centre for Radiation Research and Technology, Cairo, Egypt

Correspondence to Manal A. Shehata, PhD, Child Health Department, National Research Centre, 33 El-Bohouth Street (former El Tahrir St.), PO Box 12622, Dokki, Giza, Egypt Tel: +20 111 105 1700; fax: +20 2 337 0931; e-mail:

Received November 30, 2014

Accepted January 20, 2015

© 2015 Medical Research Journal
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