Molecular Diagnostics in Dermatology and Dermatopathology : Diagnostic Molecular Pathology

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00019606-201309000-00010Book-or-Media-ReviewDiagnostic Molecular PathologyDiagnostic Molecular Pathology© 2013 by Lippincott Williams & Wilkins.22September 2013 p 188Molecular Diagnostics in Dermatology and DermatopathologyBook ReviewBoyd, Katherine MD; Shea, Sofia MDDepartment of Pathology, University of Virginia, Charlottesville, VAThe authors declare no conflict of interest.Molecular techniques such as polymerase chain reaction, in situ hybridization, and comparative genomic hybridization have advanced in the past several decades. With these advancements, their utility in the diagnosis of a variety of disorders has become more apparent, as has the need for clinicians and pathologists to understand the methods and applicability to routine modern practice of medicine and pathology. The fields of dermatology and dermatopathology contain vast opportunities for use of molecular diagnostic techniques. The growth of knowledge and understanding of the molecular anatomy and behavior of cutaneous malignancies in particular is progressing at an astonishing rate. Therefore, never has it been more important for dermatologists and dermatopathologists to understand and apply these techniques in their modern clinical practice to facilitate diagnosis, guide treatment, and monitor therapy.This volume is part of series targeting hospital-based pathologists and residents with a goal of providing current and concise information regarding a variety of relevant topics. As Dr Murphy mentions in the preface, it is the particular aim of this volume to be a bench-side and bed-side guide for dermatologists and dermatopathologists alike in applying state-of-the-art molecular diagnostic information in daily practice.The book is hard back and printed on quality paper so as to handle easily in the lab or in the clinic. For beginners in molecular techniques, or for those who need a brief refresher, the second 2 chapters provide a basic review of molecular biology and terminology as well as brief discussions and definitions of past and current molecular techniques. The majority of the remainder of the text is conveniently divided into short chapters based on the cutaneous condition discussed within, thus allowing for easy piece-meal reading of relevant material at a given time. These include chapters on molecular diagnosis in melanoma, nonmelanoma skin cancers, soft-tissue sarcomas, and various specific cutaneous lymphomas and leukemia. Subsequent chapters address the role of molecular techniques in the diagnosis and treatment of cutaneous inflammatory and infectious disorders, as well as genodermatoses. Each chapter begins with a brief clinical background of the cutaneous neoplasm or condition being discussed, which is followed by molecular techniques used to facilitate accurate diagnosis and treatment of the topic. The final chapter, dealing with legal, ethical, and financial considerations in molecular diagnosis, is relevant to all clinicians and pathologists, regardless of specialty area. The reader will find references to Web sites containing guidelines and regulations of which to be aware before embarking on molecular diagnostic techniques in his/her own laboratory. In addition, there is a brief guide on billing and reimbursement that is invaluable to the physician and laboratory performing these tests.The color illustrations, graphs, and tables are laid out well and generally easy to interpret. Colored photomicrographs found in many of the chapters on specific skin conditions are of high quality, effectively illustrating easy-to-identify diagnostic findings. The lists of references at the back of each chapter are comprehensive and current and the index at the back of the book facilitates search by topic.As with any text of this nature, it is inevitable that rapidly expanding and adapting technologies and information will necessitate subsequent editions to ensure the lasting relevance of the book. Dr Murphy has anticipated this need by including references to online databases and other sites with frequently updated information. However, it is currently an invaluable tool, which concisely summarizes the role of molecular diagnostics for the dermatologist and the dermatopathologist in clinic, in the laboratory, and at the microscope.Katherine Boyd, MDSofia Shea, MDUniversity of Virginia, Charlottesville, VAMolecular Diagnostics in Dermatology and DermatopathologyBoyd Katherine MD; Shea, Sofia MDBook ReviewBook Review322p 188

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