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Can combined oral contraceptive be used as a hormone therapy in women with premature ovarian insufficiency?

Video Author: Cristina Laguna Benetti-Pinto
Published on: 09.23.2020
Associated with: Menopause. 27(10):1110-1116, October 2020

Hormone therapy is used in women with POI to minimize the effects of early hypoestrogenism. The video presents the results of treatment using oral contraceptives combined continuously, without pause, compared to other conventional hormonal therapies and the variation in bone mineral density.

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Creator: Risa Kagan, MD
Sponsored by Astellas Pharma Inc
Duration: 04:23
In this video, Dr. Risa Kagan describes findings from a recent study of the impact of new-onset sleep disturbances on employment and work productivity in midlife women. This retrospective, longitudinal cohort analysis used data from the Study of Women’s Health Across the Nation (SWAN), encompassing a multiracial group of women across the United States. Results showed that the risk of unemployment was higher following new-onset sleep disturbances than it is in women without sleep disturbances. The research described by Dr. Kagan also quantified the individual costs and societal economic burden associated with work productivity loss associated with new-onset sleep disturbance in midlife women.
Creator: Physicians Committee for Responsible Medicine
Duration: 04:44
Author of the Women’s Study for the Alleviation of Vasomotor Symptoms (WAVS), Neal Barnard, MD, FACC, and WAVS study participants, discuss how eating a plant-based diet, which includes soybeans, can reduce the severity and frequency of hot flashes.
Creator: Ragnhild Larsson, communications officer AgeCap
Duration: 04:25
In this video, Jenna Najar MD presents the results from the article “Reproductive period and preclinical cerebrospinal fluid markers for Alzheimer’s disease: A 25-year study”.
Creator: Robert A Wild MD MPH PHD
Duration: 06:11
Menopause BP HT Dose Formulation Timing
Creator: Wendy Ying
Duration: 03:44
Introduction to the manuscript discussing associations between menopause and echocardiographic measures of cardiac structure and function in women
Creator: Juliana Kaminski
Duration: 3:17
This video describes the rationale for our study and briefly summarizes the findings
Creator: Susanna Savukoski
Duration: 3:46
Dr. Susanna Savukoski discusses the article “Is climacterium by the mid-40s associated with thyroid dysfunction or autoimmunity? A population-based study”
Creator: Min Sun Kim
Hai Nguyen Duc
Duration: 4:55

Our research aims to determine the associations between metabolic syndrome (MetS), serum heavy metal levels, vitamin and curry rice consumption during menopause.
As it is known, over the last few decades the consumption of high-fat, saturated, high energy diets, alcohol consumption, and smoking have increased in South Korea. These lifestyle changes have resulted in a rapid increase in the prevalence of metabolic syndrome (MetS). Of note, the prevalence of MetS has increased more rapidly in women than in men due to the effects of aging and estrogen loss in menopause.

Growing evidence indicates heavy metals are a risk factor for MetS. Unfortunately, rapid industrialization and urbanization have increased heavy metal exposure.

Recent research has increased understanding of the impact of diet on MetS. For example, it has been established that daily vitamin intake and vegetable and fruit consumption reduce MetS risk in the general population. Curried rice is a popular food in Korea and contains a high concentration of curcumin, which is helpful for preventing and/or treating MetS because of its anti-oxidant and anti-inflammatory properties.

A data set of 7,131 pre- and post-menopausal women aged ≥ 20 years collected between 2009 and 2017 was used to obtain information on sociodemographic, lifestyles, family histories, food intakes, and serum heavy metal levels, and MetS.

Our results show that:

  • Postmenopausal women had a higher risk of MetS than premenopausal women.

During post-menopause:

  • Cadmium exposure increased the risk of MetS.
  • Elevated Hb levels were found to be positively associated with the prevalence of MetS, which suggests that Hb might be useful clinically to evaluate body iron status during menopause.
  • Our findings show higher HbA1c levels are associated with a significantly higher risk of MetS development during menopause. These results suggest that HbA1c levels might be a predictive clinical biomarker of MetS, insulin resistance, and type 2 diabetes during menopause.
  • High curry consumption reduced the risk of MetS significantly more than low curry consumption in premenopausal women. Furthermore, an increase in daily vitamin B2 intake by one mg reduced the risk of MetS by 45% in postmenopausal women.
Vitamin B2 and curry supplementation may protect against MetS. However, the cross-sectional design of the study prevented evaluations of causality between MetS, heavy metals, vitamin, and curry intakes. Further work is needed to reduce risk factors associated with heavy metals and to determine the effects of vitamins and curry consumption on MetS during menopause.
Creator: Dr. Michael G. Knight
Duration: 2:38
Obesity is an epidemic that affects post-menopausal women at increased rates. This review discusses the physiology, assessment, and effective treatment strategies for the treatment of obesity in this population.
Creator: Dr. Jennifer Smith
Duration: 2:32
This video describes research investigating the genetic factors associated with vasomotor symptoms in a multi-racial/multi-ethnic cohort, as presented in Zhao, et al., Menopause, 2021.
Creator: Robin Seitzman, PhD, MPH
Overview of a study to assess the effect of a web-based educational intervention on women’s healthcare provider knowledge of breast density, its risk and screening implications, and comfort level in discussing these topics with patients.
Creator: Prof Martha Hickey
Duration: 9:48
A Core Outcome Set for vasomotor & genitourinary symptoms associated with menopause: The COMMA (Core Outcomes in Menopause) global initiative.
Creator: Matti Hyvärinen
Duration: 2:57
Video summary of the longitudinal study that focused on studying the factors associated with the age at natural menopause and developing models for predicting it in middle-aged women.
Creator: Elana Felice Jaffe
Duration: 4:06
A presentation of preliminary findings from a qualitative pilot study describing experiences of the menopause transition during incarceration in a state prison or county jails.
Creator: Tomas Kovarnik
Duration: 2:55
Summary of trial assessing association between breast artery calcification (found during preventive mammography) and coronary artery disease (detected by invasive coronary angiography)
Creator: Atsushi Takahashi
Duration: 3:28
In this video, Dr. Takahashi provides a summary of article “Association of equol with obesity in postmenopausal women.”
Creator: Robert-Wild MD,MPH,PHD
Duration: 5:00
Assessing CVD risk using Framingham Risk Scores or American Heart Association ASCVD Risk Scores at baseline in the WHI Randomized Clinical Trial Cohorts more accurately predicted actual CVD events at 8.2 years and at 17.6 years follow-up than did age or years since menopause at baseline. The findings stress the importance of assessing CVD risk when Hormone Therapy is initiated. This can identify persons in need of controlling CVD risk factors and it can help better inform risk/benefit decisions. If CVD scores are elevated other risk assessments such as coronary calcium scoring might follow to enhance the accuracy of risk prediction.
Duration: 4:52
Dr. Juliana Kling, first author, describes a summary of findings from their manuscript “Associations of Sleep and Female Sexual Function: Good Sleep Quality Matters.” The evaluated potential associations between sleep (quality and duration) and sexual function using validated tools after accounting for factors that may influence both outcomes. Overall, poor sleep quality was associated with a greater risk for Female Sexual Dysfunction. While shorter sleep duration correlated with a greater risk for FSD on univariate analysis, this finding appears to be moderated by other factors known to associate with both short sleep duration and FSD. Conversely, good sleep quality was associated with sexual activity. Therefore, this study shows that sleep quality appears to be linked to female sexual function and sexual activity. In addition to its myriad effects on health, poor sleep quality may be independently associated with FSD.
Creator: Bingyan Gong
Duration: 3:53
This video describes the relationship between cognitive function, depression, and difficulty in activities of daily living in postmenopausal women.