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Development of Core Outcome Sets for Clinical Trials in Menopause - COMMA (Core OutcoMes in MenopAuse) Consortium

Video Author: Department of Obstetrics & Gynecology, University of Chicago
Published on: 08.14.2020

Dr. Monica Christmas discusses her research with the international COMMA consortium. Through COMMA, clinicians and researchers with expertise in the field of menopause, along with industry and consumers, are working together to develop Core Outcome Sets for vasomotor and genitourinary symptoms at menopause. In this video, Dr. Christmas, shares findings from a systematic review of outcomes and measurement tools reported in randomized clinical trials of interventions for genitourinary symptoms associated with menopause.

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Creator: Fatima Cody Stanford, MD, MPH, MPA
Duration: 5:25
This video explains how weight promoting medications may lead to weight gain in women during menopause. It should be noted that hormonal changes associated with menopause already lead to weight gain. However, weight gain may be exacerbated with the use of several commonly prescribed medications.
Creator: Cristina Laguna Benetti-Pinto
Duration: 3:40
Hormone therapy is used in women with POI to minimize the effects of early hypoestrogenism. The video presents the results of treatment using oral contraceptives combined continuously, without pause, compared to other conventional hormonal therapies and the variation in bone mineral density.
Creator: Dr McClung
Duration: 4:59
This video describes results of a study evaluating the effects of an osteoporosis treatment regimen of abaloparatide for 18 months followed by alendronate for 2 years on bone mineral density and general safety in a group of very elderly women.
Creator: Angelo Cagnacci
Duration: 4:32
This video describes a difference in blood pressure modification during the administration of phytoestrogens, acupuncture or hormones for the treatment of climacteric symptoms. Blood pressure decreases during phytoestrogens or acupuncture but not hormones administration. Possible mechanisms and implications are discussed.
Creator: Fundacion Dexeus Mujer
Duration: 2:28
The overall prevalence of ocular surface symptoms was 64%. It was more prevalent and more severe in postmenopausal women, whit a significant differences regarding premenopausal women. Our study found that early age at menopause was significantly associated with an increased risk of ocular surface disease symptoms.
Creator: Dr Marija Glisic
Duration: 3:40
Brief summary of rationale and most important findings.
Creator: Department of Obstetrics & Gynecology, University of Chicago
Duration: 3:41
Dr. Monica Christmas discusses her research with the international COMMA consortium. Through COMMA, clinicians and researchers with expertise in the field of menopause, along with industry and consumers, are working together to develop Core Outcome Sets for vasomotor and genitourinary symptoms at menopause. In this video, Dr. Christmas, shares findings from a systematic review of outcomes and measurement tools reported in randomized clinical trials of interventions for genitourinary symptoms associated with menopause.
Creator: E. Armeni
Duration: 3:51
Retinol binding protein 4; menopause; arterial stiffness; cardiovascular disease
Creator: Mithra Pharmaceuticals (sponsor)
Duration: 4:29
This video summarizes the results of a study to select the minimum effective dose of estetrol (E4) for the treatment of postmenopausal women with vasomotor symptoms (VMS, hot flushes). The reduction in frequency and severity of VMS was most pronounced for 15 mg E4, and was significant at week 4 and 12. E4 was well tolerated and there were no unexpected adverse events. It was concluded that oral E4 15 mg is the minimum effective daily oral dose for treatment of VMS.
Creator: Beate Sydora
Duration: 5:01
The video highlights the significance of assessing the therapeutic value of walking exercise programs for women in menopause transition and postmenopausal. Though the health benefits of exercise are well known, menopausal women are often reluctant to exercise. Walking represents fewer barriers for women in midlife as it is inexpensive, easily accessible, and has low risk of injury. Sustained walking could serve as an alternative to hormone therapy or as a beneficial addition to hormone therapy or pharmaceutical drugs. The video hints to the findings of the scoping review designed to explore the current literature on the therapeutic effect of walking programs on menopause-related symptoms and risk factors. Limitations are discussed as well as suggestions for future research.
Creator: Christina Dancz, MD
Duration: 2:54
In this video abstract, Dr. Christina Dancz from the Keck School of Medicine of the University of Southern California (USC) comments on the role of sex steroid hormones in pelvic organ prolapse. More specifically, she introduces the viewer to the effects of estrogen and progestin on ligament strength, tissue remodeling, the extracellular matrix, and clinical presentation. Taken altogether, these findings suggest that there may be a role for the exogenous administration of hormones in the prevention of pelvic organ prolapse. This topic is more fully explored in our published review in Menopause.
Creator: No sponsor
Created by Mayo Clinic
Duration: 4:22
The video reviews the findings from our paper entitled “Associations of Pituitary-Ovarian Hormones and White Matter Hyperintensities in Recently Menopausal Women using Hormone Therapy.” In recently menopausal women participating in the Kronos Early Estrogen Prevention Study (KEEPS), greater increases in estrone associated with smaller increases in WMH volume in both the transdermal estradiol and oral conjugated equine estrogen groups. In addition, greater decreases in FSH associated with smaller increases in WMH volume over time but only in women using the transdermal estrogen. Our results demonstrate that the type of hormone therapy used during menopause contributes to different levels of circulating hormones which then may have different impact on brain structure during treatment.
Creator: Purim Ruanphoo, MD.
Duration: 3:06
Introduction to the RCT of vaginal CO2 laser and sham procedure in treating vaginal atrophy.
Creator: CU-Anschutz Medical Campus, Office of Communications (contact Kristen O’Neill)
Duration: 1:51
C. Neill Epperson, MD, Chair and Robert Freedman Endowed Professor of Psychiatry at the University of Colorado-Anschutz Medical Campus highlights the significance of their study focusing on subjective and objective executive function difficulties after surgical menopause. While negative mood states (anxiety/depression) are common among individuals who endorse adverse childhood experiences (ACEs), these symptoms did not fully explain the relationship between ACEs and subjective executive function complaints or performance on working memory and sustained attention tasks. These data suggest that ACEs exert an enduring negative impact on cognition among women who experience new-onset executive function complaints after RRSO.
Creator: James Smith
Duration: 1:56
This video briefly raises the question of whether climate change will increase the incidence of menopausal hot flashes as raised in our related commentary. It challenges readers to consider what they can do to help us understand this more and prepare for these potential impacts.
Creator: Michael Shikany
Duration: 5:16
This video provides a brief overview of the Menopause manuscript, Associations of Social, Physical, and Financial Factors with Diet Quality Among Older, Community-dwelling Women
Creator: Alison Shea
Duration: 5:07
The menopause transition is a vulnerable time for mental health and it is important to better understand the risk factors for depression during this time. This study using baseline data from the Canadian Longitudinal Study on Aging shows that premature menopause and the use of hormone therapy, as well as low education, low household income, living alone, being nulliparous, and having low social support are associated with current depression measured using the Center for Epidemiologic studies Short Depression Scale.
Creator: Bence Kozma MD PhD / No Sponsor
Duration: 3:15
Many studies suggest that zinc levels may correlate with some vaginal conditions, but the role in the diagnosis of Genitourinary syndrome of Menopause or Vulvovaginal Atrophy is not known. Cervicovaginal lavage has been widely used to investigate changes in the vagina. In our prospective cohort study the multivariate regression model revealed a significant association between vaginal atrophy and cervicovaginal lavage zinc levels. Measuring the amount of zinc in cervicovaginal lavage could aid in the diagnosis of Genitourinary syndrome of Menopause. Zinc levels of cervicovaginal lavage could be used as a new marker of vaginal atrophy.
Creator: Hyun-Jin Kim
Duration: 3:19
Marriage is an important social factor that can provide protection against harmful health outcomes. There may be sex differences in the response to stress from a without spouse status. Clinicians should consider their marital status to predict subsequent cardiovascular disease.
Creator: Dr Nadav Michaan
Duration: 3:13
This video summarizes our work regarding the accuracy of ascites fluid in the diagnosis of ovarian cancer among post-menopausal patients (accuracy, sensitivity, specificity, negative and positive predictive values)