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A multicenter, randomized study to select the minimum effective dose of estetrol (E4) in postmenopausal women (E4Relief) on vasomotor symptoms

Video Author: Mithra Pharmaceuticals (sponsor)
Published on: 08.05.2020
Associated with: Menopause. 27(8):848-857, August 2020

This video summarizes the results of a study to select the minimum effective dose of estetrol (E4) for the treatment of postmenopausal women with vasomotor symptoms (VMS, hot flushes). The reduction in frequency and severity of VMS was most pronounced for 15 mg E4, and was significant at week 4 and 12. E4 was well tolerated and there were no unexpected adverse events. It was concluded that oral E4 15 mg is the minimum effective daily oral dose for treatment of VMS.

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