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Gabapentin for the treatment of hot flushes in menopause: A meta-analysis

Video Author: Chulmin Lee
Published on: 03.09.2020
Associated with: Menopause. 27(4):485-493, April 2020

Gabapentin is a plausible option for treating hot flush in menopause, especially when hormone therapy is contraindicated. This meta-analysis including 7 papers shows gabapentin reduces frequency, duration and intensity of vasomotor symptoms. Side effects such as dizziness and somnolence are tolerable.

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Creator: PING LI
Duration: 04:26
This video describes research investigating the existence of significant subgroups of women with similar menopausal symptoms. There are four subtypes of menopause symptoms in middle-aged women, namely, ‘severe symptoms’, ‘dominant sleep-emotion symptoms’, ‘physical/mental exhaustion symptoms’, and ‘no symptoms’ classes.
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Creator: Huimin Su
Duration: 04:45
Video summary of the associations of natural menopausal age with cardiovascular disease risk factors, and the modification effect of parity.
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Creator: Dr. Carole Rattray
Duration: 03:39
A conversational introduction to the research study entitled: “Mind the gap: primary care physicians and gynecologists' knowledge about menopause and their attitudes to hormone therapy use in Jamaica”.
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Creator:
Duration: 03:02
Video summary of the randomized clinical trial study that focused determining the effect of midwifery-oriented group counseling based on the GATHER model on the quality of life of women during the transition to menopause.
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Creator: Ji-Eun Kim
Duration: 03:13
Using the National Health Insurance Service database of Korea, this study examined the associations of MHT with cardiovascular diseases (CVDs) and type 2 diabetes among middle-aged postmenopausal women. This study is meaningful in evaluating these associations in Asian postmenopausal women, who were rarely included in large-scale randomized controlled trials. In addition, the time-related issues such as the immortal-time bias and the latency time bias raised from healthcare databases were corrected in the analyses.
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Creator: Conor James MacDonald
Duration: 03:05
Summary of article exploring associations between menopausal hormone therapy and risk of incident hypertension, published in Menopause
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Creator: The video was created by the authors of the article: Dr. Esteban Porrini (Voice) and Dr. Ana E. Rodríguez (design)
Duration: 07:55
In this video Dr. Esteban Porrini explains, in a presentation PowerPoint, all details of our article.
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Creator: Risa Kagan, MD
Sponsored by Astellas Pharma Inc
Duration: 04:23
In this video, Dr. Risa Kagan describes findings from a recent study of the impact of new-onset sleep disturbances on employment and work productivity in midlife women. This retrospective, longitudinal cohort analysis used data from the Study of Women’s Health Across the Nation (SWAN), encompassing a multiracial group of women across the United States. Results showed that the risk of unemployment was higher following new-onset sleep disturbances than it is in women without sleep disturbances. The research described by Dr. Kagan also quantified the individual costs and societal economic burden associated with work productivity loss associated with new-onset sleep disturbance in midlife women.
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Creator: Physicians Committee for Responsible Medicine
Duration: 04:44
Author of the Women’s Study for the Alleviation of Vasomotor Symptoms (WAVS), Neal Barnard, MD, FACC, and WAVS study participants, discuss how eating a plant-based diet, which includes soybeans, can reduce the severity and frequency of hot flashes.
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Creator: Ragnhild Larsson, communications officer AgeCap
Duration: 04:25
In this video, Jenna Najar MD presents the results from the article “Reproductive period and preclinical cerebrospinal fluid markers for Alzheimer’s disease: A 25-year study”.
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Creator: Robert A Wild MD MPH PHD
Duration: 06:11
Menopause BP HT Dose Formulation Timing
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Creator: Wendy Ying
Duration: 03:44
Introduction to the manuscript discussing associations between menopause and echocardiographic measures of cardiac structure and function in women
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Creator: Juliana Kaminski
Duration: 3:17
This video describes the rationale for our study and briefly summarizes the findings
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Creator: Susanna Savukoski
Duration: 3:46
Dr. Susanna Savukoski discusses the article “Is climacterium by the mid-40s associated with thyroid dysfunction or autoimmunity? A population-based study”
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Creator: Min Sun Kim
Hai Nguyen Duc
Duration: 4:55

Our research aims to determine the associations between metabolic syndrome (MetS), serum heavy metal levels, vitamin and curry rice consumption during menopause.
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As it is known, over the last few decades the consumption of high-fat, saturated, high energy diets, alcohol consumption, and smoking have increased in South Korea. These lifestyle changes have resulted in a rapid increase in the prevalence of metabolic syndrome (MetS). Of note, the prevalence of MetS has increased more rapidly in women than in men due to the effects of aging and estrogen loss in menopause.

Growing evidence indicates heavy metals are a risk factor for MetS. Unfortunately, rapid industrialization and urbanization have increased heavy metal exposure.

Recent research has increased understanding of the impact of diet on MetS. For example, it has been established that daily vitamin intake and vegetable and fruit consumption reduce MetS risk in the general population. Curried rice is a popular food in Korea and contains a high concentration of curcumin, which is helpful for preventing and/or treating MetS because of its anti-oxidant and anti-inflammatory properties.

A data set of 7,131 pre- and post-menopausal women aged ≥ 20 years collected between 2009 and 2017 was used to obtain information on sociodemographic, lifestyles, family histories, food intakes, and serum heavy metal levels, and MetS.

Our results show that:

  • Postmenopausal women had a higher risk of MetS than premenopausal women.

During post-menopause:

  • Cadmium exposure increased the risk of MetS.
  • Elevated Hb levels were found to be positively associated with the prevalence of MetS, which suggests that Hb might be useful clinically to evaluate body iron status during menopause.
  • Our findings show higher HbA1c levels are associated with a significantly higher risk of MetS development during menopause. These results suggest that HbA1c levels might be a predictive clinical biomarker of MetS, insulin resistance, and type 2 diabetes during menopause.
  • High curry consumption reduced the risk of MetS significantly more than low curry consumption in premenopausal women. Furthermore, an increase in daily vitamin B2 intake by one mg reduced the risk of MetS by 45% in postmenopausal women.
Vitamin B2 and curry supplementation may protect against MetS. However, the cross-sectional design of the study prevented evaluations of causality between MetS, heavy metals, vitamin, and curry intakes. Further work is needed to reduce risk factors associated with heavy metals and to determine the effects of vitamins and curry consumption on MetS during menopause.
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Creator: Dr. Michael G. Knight
Duration: 2:38
Obesity is an epidemic that affects post-menopausal women at increased rates. This review discusses the physiology, assessment, and effective treatment strategies for the treatment of obesity in this population.
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Creator: Dr. Jennifer Smith
Duration: 2:32
This video describes research investigating the genetic factors associated with vasomotor symptoms in a multi-racial/multi-ethnic cohort, as presented in Zhao, et al., Menopause, 2021.
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Creator: Robin Seitzman, PhD, MPH
Duration:
Overview of a study to assess the effect of a web-based educational intervention on women’s healthcare provider knowledge of breast density, its risk and screening implications, and comfort level in discussing these topics with patients.
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Creator: Prof Martha Hickey
Duration: 9:48
A Core Outcome Set for vasomotor & genitourinary symptoms associated with menopause: The COMMA (Core Outcomes in Menopause) global initiative.
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