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Uterine Fibroids in Menopause and Perimenopause

Video Author: Paige Wynne
Video Production Specialist
Creative and Digital Services
University of Illinois at Chicago

Published on: 01.22.2020
Associated with: February 2020, Volume 27, Issue 2; Menopause. 27(2):238-242, February 2020

In this video, we glimpse the significance of Uterine fibroid disease and highlights their unusual persistence in menopause women. Moreover, we discuss the possible available treatment options as well as the advantages and disadvantages of using hormonal therapy in this specific population.

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This video describes a systematic review of the efficacy of available interventions for sexual dysfunction in women after cancer.
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Creator: Caroline Mitchell
Duration: 5:36
In this video we discuss analysis of Female Sexual Function Index (FSFI) responses in close to 1000 women, and identify a score cutoff that more closely correlates with sexually-related personal distress (as measured by the FSDS-R) in postmenopausal and perimenopausal women.
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Duration: 5:16
This video is a summary of the manuscript titled ‘Metabolic effects of menopause: a cross-sectional characterization of body composition and exercise metabolism.’ The video discusses briefly the background, purpose, results, and conclusions of this study. Peri-menopause may be the optimal window for intervention, and these women should aim to prevent losses of fat-free mass and decrements in metabolism by participating in resistance and high-intensity exercise.
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Creator: Jiwon Lee, PhD
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This study used a structural equation model to test the significance of factors associated with the psychological well-being of midlife women in South Korea based on the transactional model of stress and coping. Self-efficacy (exogenous variable) was positively associated with the psychological well-being (endogenous variable) of middle-aged women and appeared to be mediated by perceived stress, menopausal management, menopausal symptoms, and self-compassion. The predictor variables had an explanatory power of 79.5% for psychological well-being. These results can be helpful in the future development of interventions to improve psychological well-being by improving self-efficacy and coping with stress in middle-aged women.
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Creator: Michael McClung, MD; Sponsored by TherapeuticsMD
Duration: 4:41
In this video, Dr. Michael McClung describes the effects of preparations combining 0.5 mg and 1.0 mg 17β-estradiol with 100 mg of progesterone on biochemical markers of bone metabolism in postmenopausal women with a uterus who were having moderate to severe vasomotor symptoms. This was a post hoc analysis in a subset of women in the REPLENISH study that evaluated the effects of these preparations on vasomotor symptoms. Both of the combined hormone preparations significantly reduced markers of bone resorption and formation at 6 and 12 months of therapy. The research described by Dr McClung suggests that these combinations of estradiol and progesterone may have skeletal benefit in addition to improving vasomotor symptoms in postmenopausal women.
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Creator: Aniekan Akpaffiong
Duration: 4:01
The influence of early menopause on the relationship between NT-proBNP and heart failure in postmenopausal women.
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Creator: Christine R. Langton
Duration: 3:28
This video provides a brief overview of research examining the association of oral contraceptives, tubal ligation, and anti-Müllerian hormone in the Nurses’ Health Study II cohort.
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Creator: Mankamal Kaur
Duration: 4:54
The video summarizes the statistical methods used and the major findings of the research article entitled ‘Is the cognitive performance of women sensitive to the severity of menopausal symptoms?’. The clinical implications of the current research has also been discussed in the video.
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Creator: May Wakamatsu, MD
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The video describes the importance of shared decision making and the use of decision aids with patients who are considering treatment for pelvic organ prolapse and urinary incontinence.
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Creator: Michelle Jacobson MD FRCSC NCM
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This video summarizes the paper entitled “Factors Affecting Surgical Decision Making in Carriers of Pathogenic BRCA1/2 Variants at a Hereditary Ovarian Cancer Clinic” and describes the role of the dedicated hereditary ovarian cancer clinic at a tertiary care centre.
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Creator: Gayeong Kim
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The purpose of this study was to explore the associations of race/ethnicity and menopausal status to gastrointestinal (GI) symptoms experienced during the menopausal transition while considering multiple factors that could influence the symptoms.
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Creator: Kazue Nagai
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Symptoms of urinary incontinence (e.g., stress urinary incontinence [SUI]) are relatively common in women. Furthermore, overactive bladder (OAB) syndrome occurs in approximately 10% of women. Symptoms of these conditions affect health-related quality of life. Therefore, a better understanding of the prevalence and associated factors of these urinary symptoms is required for improving and preventing these symptoms. This study investigated the prevalence and factors associated with urinary symptoms using cross-sectional data from the Japan Nurses’ Health Study in 12,198 women. The prevalence of OAB was 9.5%, that of SUI was 13.9%, and that of mixed urinary incontinence was 2.1%. Age 45-54 years and postmenopausal status was significantly associated with OAB, and age group (45–49 and 50–54 years), body mass index, and parous status were significantly associated with the risk of SUI.
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Creator: Dr. Carl Samuelsson
Duration: 3:50
Overview and summary of paper regarding bone morphology parameters measured by DXR. Powerpoint video with author going through the paper. Inner diameter of metacarpals increases in a similar fashion that bone mineral density decreases. Avenue for a screening tool?
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Creator: PING LI
Duration: 04:26
This video describes research investigating the existence of significant subgroups of women with similar menopausal symptoms. There are four subtypes of menopause symptoms in middle-aged women, namely, ‘severe symptoms’, ‘dominant sleep-emotion symptoms’, ‘physical/mental exhaustion symptoms’, and ‘no symptoms’ classes.
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Creator: Huimin Su
Duration: 04:45
Video summary of the associations of natural menopausal age with cardiovascular disease risk factors, and the modification effect of parity.
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Creator: Dr. Carole Rattray
Duration: 03:39
A conversational introduction to the research study entitled: “Mind the gap: primary care physicians and gynecologists' knowledge about menopause and their attitudes to hormone therapy use in Jamaica”.
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Duration: 03:02
Video summary of the randomized clinical trial study that focused determining the effect of midwifery-oriented group counseling based on the GATHER model on the quality of life of women during the transition to menopause.
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Creator: Ji-Eun Kim
Duration: 03:13
Using the National Health Insurance Service database of Korea, this study examined the associations of MHT with cardiovascular diseases (CVDs) and type 2 diabetes among middle-aged postmenopausal women. This study is meaningful in evaluating these associations in Asian postmenopausal women, who were rarely included in large-scale randomized controlled trials. In addition, the time-related issues such as the immortal-time bias and the latency time bias raised from healthcare databases were corrected in the analyses.
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Creator: Conor James MacDonald
Duration: 03:05
Summary of article exploring associations between menopausal hormone therapy and risk of incident hypertension, published in Menopause
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Creator: The video was created by the authors of the article: Dr. Esteban Porrini (Voice) and Dr. Ana E. Rodríguez (design)
Duration: 07:55
In this video Dr. Esteban Porrini explains, in a presentation PowerPoint, all details of our article.
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Creator: Dr. Jennifer Marino
Duration: 2:51
This video describes a systematic review of the efficacy of available interventions for sexual dysfunction in women after cancer.
Play Video |
Creator:
Duration: 5:16
This video is a summary of the manuscript titled ‘Metabolic effects of menopause: a cross-sectional characterization of body composition and exercise metabolism.’ The video discusses briefly the background, purpose, results, and conclusions of this study. Peri-menopause may be the optimal window for intervention, and these women should aim to prevent losses of fat-free mass and decrements in metabolism by participating in resistance and high-intensity exercise.
Play Video |
Creator: Aniekan Akpaffiong
Duration: 4:01
The influence of early menopause on the relationship between NT-proBNP and heart failure in postmenopausal women.
Play Video |
Creator: Christine R. Langton
Duration: 3:28
This video provides a brief overview of research examining the association of oral contraceptives, tubal ligation, and anti-Müllerian hormone in the Nurses’ Health Study II cohort.
Play Video |
Creator: Mankamal Kaur
Duration: 4:54
The video summarizes the statistical methods used and the major findings of the research article entitled ‘Is the cognitive performance of women sensitive to the severity of menopausal symptoms?’. The clinical implications of the current research has also been discussed in the video.
Play Video |
Creator: Kazue Nagai
Duration: 5:21
Symptoms of urinary incontinence (e.g., stress urinary incontinence [SUI]) are relatively common in women. Furthermore, overactive bladder (OAB) syndrome occurs in approximately 10% of women. Symptoms of these conditions affect health-related quality of life. Therefore, a better understanding of the prevalence and associated factors of these urinary symptoms is required for improving and preventing these symptoms. This study investigated the prevalence and factors associated with urinary symptoms using cross-sectional data from the Japan Nurses’ Health Study in 12,198 women. The prevalence of OAB was 9.5%, that of SUI was 13.9%, and that of mixed urinary incontinence was 2.1%. Age 45-54 years and postmenopausal status was significantly associated with OAB, and age group (45–49 and 50–54 years), body mass index, and parous status were significantly associated with the risk of SUI.
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Creator: Risa Kagan, MD
Sponsored by Astellas Pharma Inc
Duration: 04:23
In this video, Dr. Risa Kagan describes findings from a recent study of the impact of new-onset sleep disturbances on employment and work productivity in midlife women. This retrospective, longitudinal cohort analysis used data from the Study of Women’s Health Across the Nation (SWAN), encompassing a multiracial group of women across the United States. Results showed that the risk of unemployment was higher following new-onset sleep disturbances than it is in women without sleep disturbances. The research described by Dr. Kagan also quantified the individual costs and societal economic burden associated with work productivity loss associated with new-onset sleep disturbance in midlife women.
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Creator: Dr. Michael G. Knight
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Obesity is an epidemic that affects post-menopausal women at increased rates. This review discusses the physiology, assessment, and effective treatment strategies for the treatment of obesity in this population.
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Creator: Dr. Jennifer Smith
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This video describes research investigating the genetic factors associated with vasomotor symptoms in a multi-racial/multi-ethnic cohort, as presented in Zhao, et al., Menopause, 2021.
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Creator: Robin Seitzman, PhD, MPH
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Overview of a study to assess the effect of a web-based educational intervention on women’s healthcare provider knowledge of breast density, its risk and screening implications, and comfort level in discussing these topics with patients.
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Creator: Atsushi Takahashi
Duration: 3:28
In this video, Dr. Takahashi provides a summary of article “Association of equol with obesity in postmenopausal women.”
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Creator: Jee-Seon Yi
Duration: 4:38
A decision tree analysis on the associations of type II diabetes mellitus (DM) to depressive symptoms among midlife women from four major racial/ethnic groups in the U.S.
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Creator: Nikoletta Mili
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Video summary of the article entitled “Genitourinary syndrome of menopause: A systematic review on prevalence and treatment”. This article aimed to systematically review the literature to investigate the prevalence of GSM and its treatment. GSM is a highly prevalent condition among women. Nevertheless, women are frequently not aware of its cause and its treatment options. The findings of this review underline the need for education of patients and health care professionals regarding GSM diagnosis and treatment options.
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Creator: Sarah Sheehan Stadler, MD
Duration: 3:51
Review of literature regarding progesterone only for the management of menopausal symptoms
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Creator: Jennifer Gordon
Duration: 3:45
Summary of “Perimenopausal vasomotor symptoms and the cortisol awakening response”
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Creator: Fatima Cody Stanford, MD, MPH, MPA
Duration: 5:25
This video explains how weight promoting medications may lead to weight gain in women during menopause. It should be noted that hormonal changes associated with menopause already lead to weight gain. However, weight gain may be exacerbated with the use of several commonly prescribed medications.
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Creator: CU-Anschutz Medical Campus, Office of Communications (contact Kristen O’Neill)
Duration: 1:51
C. Neill Epperson, MD, Chair and Robert Freedman Endowed Professor of Psychiatry at the University of Colorado-Anschutz Medical Campus highlights the significance of their study focusing on subjective and objective executive function difficulties after surgical menopause. While negative mood states (anxiety/depression) are common among individuals who endorse adverse childhood experiences (ACEs), these symptoms did not fully explain the relationship between ACEs and subjective executive function complaints or performance on working memory and sustained attention tasks. These data suggest that ACEs exert an enduring negative impact on cognition among women who experience new-onset executive function complaints after RRSO.
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Creator: Alison Shea
Duration: 5:07
The menopause transition is a vulnerable time for mental health and it is important to better understand the risk factors for depression during this time. This study using baseline data from the Canadian Longitudinal Study on Aging shows that premature menopause and the use of hormone therapy, as well as low education, low household income, living alone, being nulliparous, and having low social support are associated with current depression measured using the Center for Epidemiologic studies Short Depression Scale.
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Creator: Bence Kozma MD PhD / No Sponsor
Duration: 3:15
Many studies suggest that zinc levels may correlate with some vaginal conditions, but the role in the diagnosis of Genitourinary syndrome of Menopause or Vulvovaginal Atrophy is not known. Cervicovaginal lavage has been widely used to investigate changes in the vagina. In our prospective cohort study the multivariate regression model revealed a significant association between vaginal atrophy and cervicovaginal lavage zinc levels. Measuring the amount of zinc in cervicovaginal lavage could aid in the diagnosis of Genitourinary syndrome of Menopause. Zinc levels of cervicovaginal lavage could be used as a new marker of vaginal atrophy.
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Creator: Dmitriy Bondarev
Duration: 4:32
Mental well-being and menopause
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Creator: Carolyn J. Crandall, MD, MS
Duration: 4:34
In this video, Dr. Carolyn J. Crandall describes the key findings and clinical “take-home messages” of the systematic review regarding safety of vaginal estrogens that her team recently performed.
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Creator: Pauline Maki
Duration: 3:31
This video describes results from a recent study examining the association between physiologic hot flashes and brain function as women learn and remember words.
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Creator: Benjamin S. Harris, MD, MPH
Duration: 2:49
The risks and benefits of hormone therapy in perimenopausal women have been extensively studied. Less is known about hormone therapy in breast or gynecologic cancer survivors and risk of cancer recurrence. We reviewed the available data to determine whether hormone therapy is safe for breast, ovarian, endometrial, and cervical cancer survivors. We also present a mechanism of reducing breast cancer incidence through estrogen-driven apoptosis pathways, and discuss the role of progestins in the growth of breast cancer stem cells. These concepts are a foundation for future research into the role of hormone replacement in treatment and prevention of breast cancer.
Play Video |
Creator: Paige Wynne
Video Production Specialist
Creative and Digital Services
University of Illinois at Chicago
Duration: 3:34
In this video, we glimpse the significance of Uterine fibroid disease and highlights their unusual persistence in menopause women. Moreover, we discuss the possible available treatment options as well as the advantages and disadvantages of using hormonal therapy in this specific population.
Play Video |
Creator: David Rogant, Cleveland Clinic
Duration: 2:49
This video presents our impetus to embark on this randomized trial and the significance of our manuscript. We discuss the innovative use of CO2 fractional laser therapy for the treatment of genitourinary syndrome of menopause (GSM) and compare it to gold standard therapy. We summarize our thoughts regarding clinical applicability of the CO2 fractional laser for GSM and make our recommendations for future work in studying its long-term efficacy and safety.
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Creator: Shannon Laughlin-Tommaso
Duration:
In this video, we discuss how hysterectomy, even with ovarian conservation, increased the long-term risks of depression and anxiety by over 20% compared with referent women. In this population-based cohort with 20 years of follow-up, hysterectomy with ovarian conservation was associated an absolute risk increase of 7% for depression and 5% for anxiety. Women who had a hysterectomy before age 36 had even higher absolute risk increases: 12% for depression and 10% for anxiety.
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Creator: Paulo Ricardo Prado Nunes
Duration: 03:26
- The exercise guidelines recommend 150 minutes/week of combined training (CT), aerobic and resistance exercises, for improvements in body composition (BC), muscle strength (MS) and physical function (PF). However, the lack of time and access to physical training facilities are commons barriers for people not to comply with the exercise guidelines.

- The high-intensity interval training (60 minutes/week - HIIT) is an exercise strategy to overcome the time commitment problem. However, there is no evidence regarding the HIIT effects on MS and PF.

- This study compared the effects of HIIT with CT on PF, BC and MS in obese postmenopausal women.
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Creator: Kathryn Bouskill et al., RAND Corporation
Duration: 4:26
This video presents an evidence map and online, interactive decision tool depicting the robustness and topical span of research on DCIS management choice on patient-centered and clinical outcomes. These tools are useful for highlighting priority areas for clinicians seeking to counsel patients regarding patient-centered outcomes for various management options for DCIS.
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Creator: Sussex Health Outcomes Research & Education in Cancer; filmed and edited by Matt Bemment, Communication Assistant, Brighton and Sussex Medical School
Duration: 4:35
What do we really know about sex after menopause? This video summary reports on the results of a free-text analysis on sexual activity in over 4,400 postmenopausal women who took part in UKCTOCS, a large UK ovarian cancer screening trial. It shows that sexuality can change when we get older and that relationship status and health have a direct effect on sexuality and satisfaction. We believe it is important to raise awareness among women and healthcare professionals to increase the understanding of sexual issues women may face in later life.
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Creator: Irwin Goldstein, MD
Duration: 3:48
This is a phase 3 pivotal trial of ospemifene versus placebo in women in menopause with moderate to severe vaginal dryness, a symptom of GSM. On physical examination, such women commonly have vulvar, vestibular and vaginal atrophy. This study, for the first time, utilized vulvar vestibular photography to objectively document changes in genital health. There were no changes noted in photography on placebo, however active therapy with a SERM resulted in regrowth of labia minora, normalization of the urethral gland prominence, resolution of the pallor and erythema of the vestibule and visualization of vestibular moisture. Visual assessment of genital health in such patients should be utilized in future trials.
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