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Hormone therapy in menopausal women with hypothyroidism

Video Author: Juliana Kaminski
Published on: 08.27.2021
Associated with: Menopause. 28(9):1044-1052, September 2021

This video describes the rationale for our study and briefly summarizes the findings

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This video is a summary of the accepted manuscript in Menopause.
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Christine Lam provides a video summary of the paper entitled, “Behavioral interventions for improving sleep outcomes in menopausal women: a systematic review and meta-analysis.” She discusses the results, significance, and future research directions of the study which aimed to review the safety and efficacy of behavioral interventions for menopause-related sleep issues.
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This video is related to the specific topic of the manuscript titled “Lipoprotein subfractions and subclinical vascular health in middle aged women: Does menopause status matter?”
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This is a video summary to accompany our paper titled “Barriers to surgical menopause counseling of gynecologic cancer patients: a quantitative and qualitative study of patients and providers.” Here, we describe our institutional mix-methods study evaluate patient and provider perspectives regarding management of and barriers to surgical menopause counseling for patients with gynecologic cancers.
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Creator: Mayra Duran, MD and Yamnia I. Cortés, PhD, MPH, FNP-BC
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Creator: Clinical Associate Professor Amanda Vincent, Monash Centre for Health Research and Implementation, Monash University, Melbourne Australia
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Early menopause, defined as menopause before age 45 years, affects up to 12% of women. This video summarizes a study evaluating the first co-designed digital resource (www.healthtalkaustralia.org) specifically for women with early menopause.
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The video introduces an article presenting data from 55 participants eligible for a randomized intervention study to treat moderate/severe postmenopausal dyspareunia. It discusses whether it deserves a broader explanation than that of atrophy. Participants described dyspareunia as “burning” and “raw.” GU examinations carefully checked for painful locations. Vulvar vestibule tenderness, rather than vaginal sensitivity, was the consistent physical finding. Liquid lidocaine could extinguish the pain. A neural phenomenon in the vestibule may be responsible for postmenopausal dyspareunia.
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This video is a summary of the manuscript titled ‘Metabolic effects of menopause: a cross-sectional characterization of body composition and exercise metabolism.’ The video discusses briefly the background, purpose, results, and conclusions of this study. Peri-menopause may be the optimal window for intervention, and these women should aim to prevent losses of fat-free mass and decrements in metabolism by participating in resistance and high-intensity exercise.
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Creator: Michael McClung, MD; Sponsored by TherapeuticsMD
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Creator: Aniekan Akpaffiong
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The video summarizes the statistical methods used and the major findings of the research article entitled ‘Is the cognitive performance of women sensitive to the severity of menopausal symptoms?’. The clinical implications of the current research has also been discussed in the video.
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Creator: Michelle Jacobson MD FRCSC NCM
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This video summarizes the paper entitled “Factors Affecting Surgical Decision Making in Carriers of Pathogenic BRCA1/2 Variants at a Hereditary Ovarian Cancer Clinic” and describes the role of the dedicated hereditary ovarian cancer clinic at a tertiary care centre.
Play
Creator: Lidia Minguez-Alarcon
Duration: 3:43
This video is a summary of the accepted manuscript in Menopause.
Play
Creator: Christine Lam
Duration: 3:08
Christine Lam provides a video summary of the paper entitled, “Behavioral interventions for improving sleep outcomes in menopausal women: a systematic review and meta-analysis.” She discusses the results, significance, and future research directions of the study which aimed to review the safety and efficacy of behavioral interventions for menopause-related sleep issues.
Play
Creator: Meiyuzhen Qi
Duration: 4:10
This video is related to the specific topic of the manuscript titled “Lipoprotein subfractions and subclinical vascular health in middle aged women: Does menopause status matter?”
Play
Creator: Connor Wang, MD
Duration: 7:01
This is a video summary to accompany our paper titled “Barriers to surgical menopause counseling of gynecologic cancer patients: a quantitative and qualitative study of patients and providers.” Here, we describe our institutional mix-methods study evaluate patient and provider perspectives regarding management of and barriers to surgical menopause counseling for patients with gynecologic cancers.
Play
Creator: Missy Richeal, Leverage Marketing
Duration: 4:32
The MTS is a thorough patient-centric survey to measure symptoms of menopause as women transition in the outpatient setting.
Play
Creator: Linda Besant
Duration: 5:47
The video introduces an article presenting data from 55 participants eligible for a randomized intervention study to treat moderate/severe postmenopausal dyspareunia. It discusses whether it deserves a broader explanation than that of atrophy. Participants described dyspareunia as “burning” and “raw.” GU examinations carefully checked for painful locations. Vulvar vestibule tenderness, rather than vaginal sensitivity, was the consistent physical finding. Liquid lidocaine could extinguish the pain. A neural phenomenon in the vestibule may be responsible for postmenopausal dyspareunia.
Play
Creator:
Duration: 5:16
This video is a summary of the manuscript titled ‘Metabolic effects of menopause: a cross-sectional characterization of body composition and exercise metabolism.’ The video discusses briefly the background, purpose, results, and conclusions of this study. Peri-menopause may be the optimal window for intervention, and these women should aim to prevent losses of fat-free mass and decrements in metabolism by participating in resistance and high-intensity exercise.
Play
Creator: Aniekan Akpaffiong
Duration: 4:01
The influence of early menopause on the relationship between NT-proBNP and heart failure in postmenopausal women.
Play
Creator: Mankamal Kaur
Duration: 4:54
The video summarizes the statistical methods used and the major findings of the research article entitled ‘Is the cognitive performance of women sensitive to the severity of menopausal symptoms?’. The clinical implications of the current research has also been discussed in the video.
Play
Creator: May Wakamatsu, MD
Duration: 4:15
The video describes the importance of shared decision making and the use of decision aids with patients who are considering treatment for pelvic organ prolapse and urinary incontinence.
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The menopause transition is a vulnerable time for mental health and it is important to better understand the risk factors for depression during this time. This study using baseline data from the Canadian Longitudinal Study on Aging shows that premature menopause and the use of hormone therapy, as well as low education, low household income, living alone, being nulliparous, and having low social support are associated with current depression measured using the Center for Epidemiologic studies Short Depression Scale.
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Many studies suggest that zinc levels may correlate with some vaginal conditions, but the role in the diagnosis of Genitourinary syndrome of Menopause or Vulvovaginal Atrophy is not known. Cervicovaginal lavage has been widely used to investigate changes in the vagina. In our prospective cohort study the multivariate regression model revealed a significant association between vaginal atrophy and cervicovaginal lavage zinc levels. Measuring the amount of zinc in cervicovaginal lavage could aid in the diagnosis of Genitourinary syndrome of Menopause. Zinc levels of cervicovaginal lavage could be used as a new marker of vaginal atrophy.
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Prof. Angelica Linden Hirschberg describes main aspects of the Blissafe Study, a European multinational investigation conducted in collaboration with clinical oncologists and gynecologists, and underlines the clinical relevance of the results. Ultra-low-dose 0.005% estriol vaginal gel has demonstrated efficacy over severe vulvovaginal symptoms experienced by women with breast cancer, while no relevant increase of plasmatic estrogens or variation of hypophyseal hormones is observed after treatment.
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Dr. Holly Thomas, Associate Professor of Medicinefrom the University of Pittsburgh describes herresearch, in which she conducted interviews andfocus groups with women aged 60 and older toidentify causes of low libido. Postmenopausalvaginal symptoms, erectile dysfunction in malepartners, and life stressors were identified as majorcontributors. She ends with recommendations forhealthcare providers.
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Video Production Specialist
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In this video, we glimpse the significance of Uterine fibroid disease and highlights their unusual persistence in menopause women. Moreover, we discuss the possible available treatment options as well as the advantages and disadvantages of using hormonal therapy in this specific population.
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Creator: David Rogant, Cleveland Clinic
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This video presents our impetus to embark on this randomized trial and the significance of our manuscript. We discuss the innovative use of CO2 fractional laser therapy for the treatment of genitourinary syndrome of menopause (GSM) and compare it to gold standard therapy. We summarize our thoughts regarding clinical applicability of the CO2 fractional laser for GSM and make our recommendations for future work in studying its long-term efficacy and safety.
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Creator: Paulo Ricardo Prado Nunes
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- The exercise guidelines recommend 150 minutes/week of combined training (CT), aerobic and resistance exercises, for improvements in body composition (BC), muscle strength (MS) and physical function (PF). However, the lack of time and access to physical training facilities are commons barriers for people not to comply with the exercise guidelines.

- The high-intensity interval training (60 minutes/week - HIIT) is an exercise strategy to overcome the time commitment problem. However, there is no evidence regarding the HIIT effects on MS and PF.

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Creator: Sussex Health Outcomes Research & Education in Cancer; filmed and edited by Matt Bemment, Communication Assistant, Brighton and Sussex Medical School
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What do we really know about sex after menopause? This video summary reports on the results of a free-text analysis on sexual activity in over 4,400 postmenopausal women who took part in UKCTOCS, a large UK ovarian cancer screening trial. It shows that sexuality can change when we get older and that relationship status and health have a direct effect on sexuality and satisfaction. We believe it is important to raise awareness among women and healthcare professionals to increase the understanding of sexual issues women may face in later life.
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Creator: Irwin Goldstein, MD
Duration: 3:48
This is a phase 3 pivotal trial of ospemifene versus placebo in women in menopause with moderate to severe vaginal dryness, a symptom of GSM. On physical examination, such women commonly have vulvar, vestibular and vaginal atrophy. This study, for the first time, utilized vulvar vestibular photography to objectively document changes in genital health. There were no changes noted in photography on placebo, however active therapy with a SERM resulted in regrowth of labia minora, normalization of the urethral gland prominence, resolution of the pallor and erythema of the vestibule and visualization of vestibular moisture. Visual assessment of genital health in such patients should be utilized in future trials.
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