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Therapeutic effects of whole-body vibration on fracture healing in ovariectomized rats

a systematic review and meta-analysis

Chen, Jinman, BS1,2,3,4; Ruan, Hongfeng, PhD1,2,4; Liu, Yang, BS1,2,4; Bao, Jiamin, BS1,2,3,4; Xu, Hao, PhD1,2,4; Yao, Min, PhD1,2,4; Cui, Xuejun, PhD1,2,4; Liang, Qianqian, PhD1,2,4; Wang, Yongjun, PhD1,2,3,4

doi: 10.1097/GME.0000000000001285
Original Articles

Objective: Whole-body vibration (WBV), providing cyclic mechanical stimulation, has been used to accelerate fracture healing in preclinical studies. This study aimed to summarize and evaluate the effects of WBV on bone healing in ovariectomized rat models and then analyze its potential effects on fractures in human postmenopausal osteoporosis.

Methods: PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, VIP, SinoMed, and WanFang databases were searched from their inception date to September 2017, and an updated search was conducted in January 2018. Studies that evaluated the effects of WBV on bone healing compared with control groups in ovariectomized rats were included. Two authors selected studies, extracted data, and assessed the methodological quality. Meta-analyses were performed when the same outcomes were reported in two or more studies.

Results: Nine eligible studies were selected. In treatment groups, callus areas were significantly improved in the first 3 weeks, normalized total bone volume and total tissue volume values increased dramatically at 8 weeks, and the mechanical tests showed a significant difference at the end point of the study.

Conclusions: This study suggested that WBV could accelerate callus formation in the early phase of bone healing, promote callus mineralization and maturity in the later phase, and restore mechanical properties of bones.

1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

2Institute of Spine Disease, Shanghai University of Traditional Chinese Medicine, Shanghai, China

3School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China

4Key Laboratory of theory and therapy of muscles and bones, Ministry of Education, Shanghai, China.

Address correspondence to: Yongjun Wang, PhD, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Rd, Shanghai 201203, China. E-mail:; Qianqian Liang, PhD, Institute of Spine, Shanghai University of Traditional Chinese Medicine, 725 Wan-Ping South Rd, Shanghai 200032, China. E-mail:

Received 19 August, 2018

Revised 2 November, 2018

Accepted 2 November, 2018

Funding/support: This work was sponsored by research grants from the National Natural Science Foundation (81730107, 81330085, 81822050, and 81673990), Shanghai Scientific Research project (17401971100), the first round of a 3-year action plan to promote clinical skills and clinical innovation in municipal hospitals (16CR1017A), Shanghai TCM Medical Center of Chronic Disease (2017ZZ01010), the program for innovative research of the Ministry of Science and Technology of China (2015RA4002), and “Innovation Team” development projects (IRT1270). Three Years Action to Accelerate the Development of Traditional Chinese Medicine Plan (ZY(2018-2020)-CCCX-3003 to W.Y.J.).

Financial disclosure/conflicts of interest: The authors report no conflicts of interests.

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Online date: December 17, 2018

© 2019 by The North American Menopause Society.