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25-Hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve

Jukic, Anne Marie Z. PhD1; Baird, Donna D. PhD2; Wilcox, Allen J. MD, PhD2; Weinberg, Clarice R. PhD3; Steiner, Anne Z. MD4

doi: 10.1097/GME.0000000000001075
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Objective: The aim of the study was to examine the associations between 25-hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve in a large community-based sample of women.

Methods: In 2010 to 2016, women aged 30 to 44 years without any known fertility problems were recruited from the Chapel Hill, NC area for a prospective time-to-pregnancy cohort study. At enrollment 561 women provided a blood sample that was used to measure 25(OH)D, anti-Müllerian hormone (AMH), follicle-stimulating hormone, and inhibin-B. Unadjusted associations were estimated with Spearman correlation coefficients. Multivariable linear regression was used to estimate associations of 25(OH)D with ovarian reserve biomarkers, after adjusting for age, race, body mass index, smoking history, and recent use of hormonal birth control.

Results: The mean 25(OH)D was 36 ng/mL (SD = 11 ng/mL). 25(OH)D was not correlated with AMH, follicle-stimulating hormone, or inhibin-B (all r < 0.03). Multivariable results with continuous hormonal outcomes were also null. For dichotomous outcomes, there was a tendency for insufficient 25(OH)D (<30 ng/mL) to be associated with low AMH (<0.7 ng/mL) (odds ratio [95% CI]: 1.8 [0.9-4]).

Conclusions: For the most part, 25(OH)D was not associated with ovarian reserve biomarkers in a group of women trying to become pregnant. We found some evidence that low 25(OH)D (<30 ng/mL) was associated with low AMH, but this should be confirmed in studies with a higher prevalence of low 25(OH)D.

1Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT

2Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC

3Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC

4Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Address correspondence to: Anne Marie Z. Jukic, PhD, One Church St, 6th Floor, New Haven, CT 06510. E-mail: annemarie.jukic@yale.edu

Received 12 October, 2017

Revised 20 December, 2017

Accepted 20 December, 2017

Authors’ contributions: AMZJ conceived of the study, designed, and interpreted the analysis, and wrote the first draft of the manuscript. AJW, CRW, and DDB provided input on the design and interpretation of the study and edited the manuscript. AZS designed and implemented the parent study, Time to Conceive, and provided input on the present study design, analysis, and interpretation, and edited the manuscript.

Funding/support: This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (NIH) under award numbers R00HD079659 and R01HD067683. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This research was also supported, in part, by the intramural research program of the NIEHS, NIH (Z01ES044003-39).

Financial disclosure/conflicts of interest: None reported.

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© 2018 by The North American Menopause Society.