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Body iodine status in women with postmenopausal osteoporosis

Arslanca, Tufan MD1; Korkmaz, Vakkas MD2; Arslanca, Seyma B. MD3; Karadag, Burak MD4; Ergün, Yusuf MD2

doi: 10.1097/GME.0000000000000987
Original Articles

Objective: Postmenopausal osteoporosis is a frequent cause of morbidity and can negatively impact life expectancy; iodine is an essential element for bone mineralization, and iodine deficiency is frequently observed. The aim of the present study was to understand the connection between postmenopausal osteoporosis and the level of iodine in the body.

Methods: A total of 132 participants were divided into three groups: group 1 consisted of healthy postmenopausal women (n = 34), group 2 comprised osteopenic women (n = 38), and group 3 included women with postmenopausal osteoporosis (n = 60). The three groups were compared according to demographic, clinical, and laboratory findings.

Results: The urinary iodine levels were recorded as 216.1 ± 125.2 in the control group, 154.6 ± 76.6 in the osteopenic group, and 137.5 ± 64.9 in the postmenopausal osteoporosis group (P < 0.001). These differences were maintained after adjustment for body mass index (P < 0.001). The urinary iodine level accurately correlated with the total T-score for the lumbar spine (r = 0.236, P = 0.008). Multiple regression analysis showed that corrected for body mass index, alkaline phosphatase isoenzyme, and urinary deoxypyridinoline, the urinary iodine level was significantly associated with total T-score (beta coefficient = 0.270, P = 0.006).

Conclusions: The urinary iodine level was significantly lower in women with postmenopausal osteoporosis, and iodine replacement may be important in preventing osteoporosis in areas where iodine deficiency is endemic.

1Department of Obstetrics and Gynecology, Yenimahalle Training and Research Hospital, Ankara, Turkey

2Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey

3Department of Obstetrics and Gynecology, Ankara University Hospital, Ankara, Turkey

4Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Antalya, Turkey.

Address correspondence to: Tufan Arslanca, MD, Department of Obstetrics and Gynecology, Yenimahalle Training and Research Hospital, Ankara, Turkey. E-mail:

Received 26 April, 2017

Revised 14 August, 2017

Accepted 14 August, 2017

Funding/support: No financial support of any kind was received for this study.

Financial disclosure/conflicts of interest: None reported.

© 2018 by The North American Menopause Society.