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Systemic hypertension and diabetes mellitus as predictors of malignancy among women with endometrial polyps

a meta-analysis of observational studies

Pergialiotis, Vasilios MD, MSc, PhD; Prodromidou, Anastasia MD; Siotos, Charalampos MD; Frountzas, Maximos MD; Perrea, Despina PhD; Vlachos, Georgios D. PhD

doi: 10.1097/GME.0000000000000602
Review Article
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Objective: Diabetes mellitus (DM) and systemic hypertension (SH) are frequent benign diseases which might coexist with endometrial polyps. We sought to evaluate whether women who suffer from these diseases have an increased incidence of premalignant and malignant lesions.

Methods: We systematically searched the literature using the Medline (by using Pubmed) (1966-2015), Scopus (2004-2015), ClinicalTrials.gov (2008-2015), Cochrane Central Register (CENTRAL), and Google Scholar (2004-2015) databases along with the references of all articles which were retrieved in full text. We performed the meta-analysis with the RevMan 5.1 software.

Results: Both DM and SH seem to be correlated with increased odds of developing premalignant and malignant endometrial polyps (odds ratio 2.43, 95% confidence interval 1.51, 3.91) and (odds ratio 2.36, 95% confidence interval 1.16, 4.81). However, it remains unclear whether type I or type II DM exert a more pronounced effect and whether the severity of SH has an impact on these odds. Also, the potential relation of antidiabetic and antihypertensive treatment with these lesions cannot be excluded.

Conclusions: Physicians should increase their awareness among women with endometrial polyps who suffer from DM and/or SH. Further studies are needed to corroborate our findings and elucidate the underlying mechanisms of this relation.

1Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece

2First dpt of Ob/Gyn, Division of Gynecologic Oncology, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.

Address correspondence to: Vasilios Pergialiotis, MD, MSc, PhD, 6, Danaidon str, Halandri 15232, Greece. E-mail: pergialiotis@yahoo.com

Received 13 August, 2015

Revised 16 October, 2015

Accepted 30 November, 2015

Funding/support: None.

Financial disclosure/conflicts of interest: None reported.

© 2016 by The North American Menopause Society.