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Bone structure and turnover in postmenopausal women with type 2 diabetes mellitus

Razi, Farideh MD; Esmaili, Mahnaz MS; Esfahani, Ensieh Nasli MD; Yaghmaei, Parichehreh PhD; Qorbani, Mostafa MD; Mohammadi, Zahra MS; Keshtkar, Abbasali MD; Khashayar, Patricia MD; Larijani, Bagher MD

doi: 10.1097/GME.0000000000000524
Original Articles
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Objective: Considering the high prevalence of diabetes and osteoporosis in Iranians, the current research was conducted to study the correlation between these two diseases in a group of postmenopausal women.

Methods: The present study was conducted on postmenopausal women recruited in the third phase of the Iranian Multi-centric Osteoporosis Study. They were divided into two groups (diabetic and nondiabetic) based on their diabetes history and laboratory results. The serum levels of bone markers and bone mineral density values were compared between the two groups.

Results: A total of 110 postmenopausal women were included. Although bone mineral density values were nonsignificantly higher in diabetic postmenopausal women, there was no considerable difference between the prevalence of osteoporosis or serum levels of bone markers in the two groups.

Conclusions: There is no difference in bone mass values or bone turnover process between Iranian postmenopausal women with or without diabetes.

1Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

2Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

3Department of Community Medicine, Alborz University of Medical Sciences, Karaj, Iran

4Department of Epidemiology and Biostatistics, Iran University of Medical Sciences, Tehran, Iran

5Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

6Department of Health Sciences Education Development, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

7Center for Microsystems Technology, Imec and Ghent University, Gent-Zwijnaarde, Belgium

8Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Address correspondence to: Patricia Khashayar, MD, Center for Microsystems Technology, Imec and Universiteit Gent, Zwinjaarde, Belgium. E-mail: patricia.kh@gmail.com

Received 3 April, 2015

Revised 15 June, 2015

Accepted 15 June, 2015

Funding/support: This work was supported by Iranian Ministry of Health and Medical Education.

Financial disclosure/conflicts of interest: None reported.

© 2016 by The North American Menopause Society.