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Caffeine and menopausal symptoms

what is the association?

Faubion, Stephanie S. MD; Sood, Richa MD; Thielen, Jacqueline M. MD; Shuster, Lynne T. MD

doi: 10.1097/GME.0000000000000301
Original Articles

Objective We assessed the association between caffeine intake and menopausal symptom bother, particularly vasomotor symptoms.

Methods A cross-sectional survey was conducted using the Menopause Health Questionnaire, which is a comprehensive survey of menopause-related health information. Questionnaires were completed by 2,507 consecutive women who presented with menopausal concerns at the Women’s Health Clinic at Mayo Clinic (Rochester, MN) between July 25, 2005 and July 25, 2011. Data from 1,806 women who met all inclusion criteria were analyzed. Menopausal symptom ratings were compared between women who used caffeine and women who did not use caffeine using two-sample t test and analysis of covariance, with smoking and menopause status included as covariates. In all cases, two-tailed P < 0.05 was considered statistically significant.

Results Caffeine use was positively associated with mean (SD) vasomotor symptom scores (2.30 [0.91] vs 2.15 [0.94], P = 0.011). This finding remained significant after adjustment for menopause status and cigarette smoking (P = 0.027).

Conclusions Caffeine use is associated with greater vasomotor symptom bother in postmenopausal women.

From the General Internal Medicine, Women’s Health Clinic, Mayo Clinic, Rochester, MN.

Received January 22, 2014; revised and accepted May 30, 2014.

The contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.

Funding/support: This publication was supported by grant UL1 TR000135 from the National Center for Advancing Translational Sciences.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Stephanie S. Faubion, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. E-mail:

© 2015 by The North American Menopause Society.