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Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women

Yang, Rong MD; Ma, Xiaojing MD; Pan, Xiaoping BS; Wang, Feifei MD; Luo, Yuqi MD; Gu, Chengchen BS; Bao, Yuqian MD; Jia, Weiping MD, PhD

doi: 10.1097/gme.0b013e318271b1da
Original Articles

Objective It has been revealed that osteocalcin is a regulator of energy metabolism. We investigated the relationship between serum osteocalcin levels and metabolic syndrome (MetS) in Chinese postmenopausal women.

Methods A total of 1,789 postmenopausal women, aged 41 to 78 years, were selected from four communities in Shanghai, China. Serum levels of osteocalcin were measured with an electrochemiluminescence immunoassay. The diagnostic definition of MetS followed the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults.

Results Serum osteocalcin levels were significantly lower in participants with MetS than in non-MetS participants (median [interquartile range], 18.51 [15.52-23.46] vs 21.09 [16.98-26.26] ng/mL, P < 0.01). The frequency of MetS and its components decreased with increasing increments of serum osteocalcin levels (all P for trend < 0.05), with the exception of the frequency of low levels of high-density lipoprotein cholesterol. Serum osteocalcin levels significantly decreased with increasing number of metabolic disorders (P for trend < 0.01). Furthermore, binary logistic regression analysis revealed that participants with higher serum osteocalcin levels had lower odds ratios (ORs) for MetS (OR, 0.123; 95% CI, 0.053-0.283), central obesity (OR, 0.134; 95% CI, 0.060-0.299), and hyperglycemia (OR, 0.142; 95% CI, 0.066-0.302).

Conclusions Serum osteocalcin levels are negatively associated with MetS, particularly central obesity and hyperglycemia, in Chinese postmenopausal women.

From the Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

Received June 19, 2012; revised and accepted August 29, 2012.

R.Y. and X.M. contributed equally to this work.

Funding/support: This work was funded by the 973 Program of China (2012CB524906), the Project of the National Natural Science Foundation of China (81170788 and 81100563), the National Key Technology R&D Program of China (2012BAI02B03), and the Key Project of Science and Technology of Shanghai (09DZ1950202).

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Yuqian Bao, MD, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, China. E-mail:

© 2013 by The North American Menopause Society.