Original ArticlesEffect of soy isoflavone supplementation on menopausal quality of lifeAmato, Paula MD1; Young, Ronald L. MD1; Steinberg, Francene M. PhD2; Murray, Michael J. MD3; Lewis, Richard D. PhD4; Cramer, Margaret A. MD4; Barnes, Stephen PhD5; Ellis, Kenneth J. PhD6; Shypailo, Roman J. BS6; Fraley, Joe Kennard MPH6; Konzelmann, Karen L. MS6; Fischer, Joan G. PhD4; LaSalle, Colette RD2; Smith, Elliot O’Brian PhD6; Wong, William W. PhD6Author Information From the 1Oregon Health and Science University, Portland, OR; 2University of California, Davis, CA; 3Kaiser Foundation Research Institute, Sacramento, CA; 4University of Georgia, Athens, GA; 5University of Alabama, Birmingham, AL; and 6US Department of Agriculture/Agricultural Research Service, Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX. Received May 30, 2012; revised and accepted September 6, 2012. Funding/support: This study was supported by the US Department of Agriculture/Cooperative State Research, Education, and the Extension Service/Initiatives for Future Agriculture and Food Systems (grant 2001-52102-11255) and by the National Institutes of Health General Clinical Research Center (grant M01-RR00188). Financial disclosure/conflicts of interest: W.W.W. is a consultant to Nestle. All other authors report no conflicts of interest. Address correspondence to: Paula Amato, MD, Oregon Health and Science University, 3303 SW Bond Avenue, CH10F, Portland, OR 97239-4501. E-mail: [email protected] Menopause: April 2013 - Volume 20 - Issue 4 - p 443-447 doi: 10.1097/gme.0b013e318275025e Buy Metrics Abstract Objective The purpose of this study was to assess the effect of soy isoflavone supplementation on quality of life in postmenopausal women. Methods A multicenter, randomized, double-blind, placebo-controlled 24-month trial was conducted to assess the effect of 80 or 120 mg of daily aglycone hypocotyl soy isoflavone supplementation on quality of life in 403 postmenopausal women using a validated Menopause-Specific Quality of Life questionnaire. Results Menopause-Specific Quality of Life domain scores at 1 year and 2 years were similar to baseline. There were no differences in domain scores among treatment groups. Conclusions Soy isoflavone supplementation offers no benefit to quality of life in postmenopausal women. © 2013 by The North American Menopause Society.