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Serum lipid levels in women with premature ovarian failure

Gulhan, Ibrahim MD1; Bozkaya, Giray MD1; Uyar, Ibrahim MD2; Oztekin, Deniz MD2; Pamuk, Baris Onder MD1; Dogan, Erbil MD3

doi: 10.1097/gme.0b013e318254102b
Original Articles

Objective The aim of this study was to investigate serum lipid and hormone levels in women with premature ovarian failure (POF) and compare them with those of healthy women of similar age.

Methods We measured fasting total cholesterol (TC), triglyceride, low-density lipoprotein (LDL), high-density lipoprotein, estradiol (E2), follicle-stimulating hormone (FSH), progesterone, and testosterone levels in 47 women with POF not using any hormone therapy and 60 healthy women of the same age range not using oral contraceptives or any other hormonal medication.

Results There were no statistically significant differences between the groups in terms of age, body mass index (BMI) and smoking status (P = 0.054, 0.250, and 0.656, respectively). The mean E2 levels of the POF and control groups were 27.9 ± 2.3 and 87.8 ± 75.2 pg/mL, respectively (P < 0.001). Women with POF presented with significantly higher TC and LDL levels (P = 0.006 and 0.040, respectively). However, no difference was found between the groups with regard to triglyceride and high-density lipoprotein levels (P = 0.128 and 0.062, respectively). We determined that there was a significant negative correlation between E2 and TC levels (r = −0.291, P = 0.047) in the POF group. However, no correlation could be identified between E2 and lipids in the control group. Likewise, no correlation was present between FSH and lipids in both groups. We divided the control group according to basal FSH level. Group A consisted of the women with a serum FSH level lower than 7 IU/L, and group B consisted of the women with a serum FSH level of 7 IU/L or higher. There was no difference between the groups in age, body mass index, E2 concentration, and smoking status. The FSH level of group A was significantly lower than that of group B (P < 0.001). We found no difference between groups A and B with regard to lipid levels.

Conclusions Higher TC and LDL levels in women with POF compared with the control group suggest that estrogen deprivation in women with POF leads to unfavorable lipid changes.

From the 1Izmir Bozyaka Research Hospital, Izmir, Turkey; 2Ege Maternity and Gynecology Training and Research Hospital, Izmir, Turkey; and 3Faculty of Medicine, Department of Gynecology and Obstetrics, Dokuz Eylul University, Izmir, Turkey.

Received January 11, 2012; revised and accepted March 5, 2012.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Ibrahim Gulhan, MD, Izmir Bozyaka Egitim ve Arastirma Hastanesi, KadNn Dogum Klinigi, Bozyaka-Izmir, Turkey 35300. E-mail:

©2012The North American Menopause Society