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The relationship between blood mercury level and osteoporosis in postmenopausal women

Cho, Geum Joon MD; Park, Hyun Tae MD; Shin, Jung Ho MD; Hur, Jun Young MD; Kim, Sun Haeng MD; Lee, Kyu Wan MD; Kim, Tak MD, PhD

doi: 10.1097/gme.0b013e3182377294
Original Articles

Objective Postmenopausal women have a higher prevalence of osteoporosis compared with premenopausal women. Postmenopause status has been found to be an independent risk factor for osteoporosis. Several studies have reported that heavy metals, including lead (Pb), mercury (Hg), cadmium (Cd), and arsenic (As), have detrimental effects on bone. The aim of this study was to evaluate the association among heavy metals, including Pb, Hg, Cd, and As, bone mineral density, and osteoporosis in postmenopausal Korean women.

Methods We conducted a cross-sectional study of 481 postmenopausal women, all of whom were enrolled in the Korean National Health and Nutrition Examination Survey in 2008. Bone mineral density was measured using dual-energy x-ray absorptiometry. Blood Pb, Hg, and Cd and urinary As levels were measured.

Results Postmenopausal women with higher blood Hg levels were more likely to be younger and have higher vitamin D levels, fish consumption, and prevalence of osteoporosis. On multivariate logistic regression analysis, postmenopausal women with blood Hg levels in the fourth quartile had a 0.36-fold decreased risk of having osteoporosis compared with those with levels in the first quartile, after adjustments for age, body mass index, alcohol intake, smoking history, exercise, use of oral contraceptive pills, hormone therapy, intake of caloric energy and calcium, fish consumption, and vitamin D level. However, there was no association between other heavy metals and osteoporosis.

Conclusions High blood Hg levels were associated with a lower risk of having osteoporosis in postmenopausal women. Because biomarkers of all four metals measured in this study reflect recent exposures, further studies are necessary to clarify the association of osteoporosis with the level of heavy metals in biomarkers for long-term exposure such as hair or fingernail.

In this study, high blood mercury levels were associated with a lower risk of having osteoporosis in postmenopausal women.

From the Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.

Received June 10, 2011; revised and accepted September 6, 2011.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Tak Kim, MD, PhD, Department of Obstetrics and Gynecology, Korea University Anam Hospital, Korea University College of Medicine, 126-1, 5-ga Anam-dong, Seongbuk-gu, Seoul 136-705, Korea. E-mail:

©2012The North American Menopause Society