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Vascular resistance of central retinal and ophthalmic arteries in postmenopausal women after use of tibolone

de Souza, Marco Aurélio Martins MD, PhD1; de Souza, Bruno Martins MS2; Geber, Selmo MD, PhD2

Menopause: The Journal of The North American Menopause Society: March 2012 - Volume 19 - Issue 3 - p 328–331
doi: 10.1097/gme.0b013e3182290b26
Original Articles
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Objective The aim of this study was to evaluate the effect of tibolone on vascular resistance of the central retinal and ophthalmic artery in postmenopausal women and to compare this effect with that of placebo using transorbital ultrasound with Doppler velocimetry.

Methods We performed a prospective randomized, double-blinded, placebo-controlled study. A total of 100 healthy postmenopausal women (follicle-stimulating hormone, >40 IU/L) younger than 65 years were studied. The participants were randomly allocated to two groups: placebo (n = 50) and tibolone (2.5 mg; n = 50). Transorbital Doppler velocimetric ultrasound was performed before treatment and 80 days after.

Results The mean age was similar in both groups. Participants who received tibolone did not show any difference in pulsatility index, resistance index, and systole/diastole ratio of the central retinal and ophthalmic arteries after treatment. The same was observed in participants who received placebo.

Conclusions Our study demonstrates that tibolone administration to healthy postmenopausal women does not affect the resistance of small-caliber cerebral arteries.

The use of tibolone does not interfere with the vascular resistance of the central retinal and ophthalmic arteries in postmenopausal women.

From the 1UNIMONTES Medical School, Montes Claros, Minas Gerais, Brazil; and 2Department of Obstetrics & Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Received May 15, 2011; revised and accepted June 13, 2011.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Selmo Geber, MD, PhD, Av do contorno 7747, Lourdes - CEP: 30110120, Belo Horizonte, Minas Gerais, Brazil. E-mail: selmogeber@origen.com.br

©2012The North American Menopause Society