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Endocrine regulation of the course of menopause by oral melatonin: first case report

Díaz, Beatriz López PhD1; Llaneza, Plácido Coto MD, PhD2

doi: 10.1097/gme.0b013e31812503f2
Case Report
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Objective: The pineal gland, through its hormone melatonin, is involved in the mechanisms that regulate the aging process involved in the onset of menopause. Considering the melatonin changes reported during pre-, peri-, and postmenopause, an influence of melatonin on the hormonal changes associated with menopause transition could be expected.

Design: We report the first longitudinal case study, covering a 7.5-year period, on the effects of melatonin administration on the reproductive hormones luteinizing hormone, follicle-stimulating hormone, and 17β-estradiol during that period of the reproductive life.

Results and Conclusion: The data obtained in this case report show that melatonin administration was able to delay the characteristic endocrine changes that occur during the course of menopause.

The data obtained in this case report show for the first time that melatonin was able to delay the characteristic endocrine parameters associated with menopause onset.

From the 1Departamento de Biología Funcional, Área Fisiología, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain; and 2Hospital Universitario Central de Asturias, Servicio de Ginecología, Oviedo, Spain.

Received March 5, 2007; revised and accepted May 23, 2007.

Financial disclosure: None reported.

Address correspondence to: Beatriz López Díaz, PhD, Departamento de Biología Funcional, Área Fisiología, Facultad de Medicina, C/Julián Clavería 8, 33006 Oviedo, Spain. E-mail: beatrizd@uniovi.es

©2008The North American Menopause Society