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Development and preliminary validation of the Menopause Symptoms Treatment Satisfaction Questionnaire (MS-TSQ)

Hill, Cheryl D. PhD1; Fehnel, Sheri E. PhD1; Bobula, Joel D. MA2; Yu, Holly MSPH2; McLeod, Lori D. PhD1

doi: 10.1097/gme.0b013e31803816b8
Articles

Objective: The Menopause Symptoms Treatment Satisfaction Questionnaire, an eight-item questionnaire with a 4-week recall period, was developed to assess women's satisfaction with treatment for symptoms associated with menopause. We describe the development and initial testing of the scale.

Design: Following standard instrument-development procedures, focus groups were conducted with menopausal women experiencing hot flushes to generate potential constructs. Multiple items were drafted to address each construct. An iterative process of cognitive testing, item revision, and item reduction was followed to identify the most appropriate items and optimal response scales. The psychometric validation of the questionnaire used data collected through a multicenter, randomized, double-blind, placebo-controlled study including 543 postmenopausal women. Psychometric analyses were conducted to explore potential item reduction and to address questionnaire scaling and scoring. Internal consistency reliability, construct validity, and discriminant validity of the new scale were also examined.

Results: The questionnaire includes items addressing the control of daytime and nighttime hot flushes; effects of treatment on sleep, mood, libido, and cognition; medication tolerability; and overall satisfaction. Correlation analyses indicated that the items are related to each other without being overly redundant and that the item set is best described using a one-factor model. The subsequent scale score demonstrated sound internal consistency reliability, strong construct validity, and good discriminant validity.

Conclusions: The results of the development and initial validation are favorable. It is expected that the questionnaire will prove to be a worthwhile tool for assessing women's satisfaction with treatment for menopausal symptoms.

The Menopause Symptoms Treatment Satisfaction Questionnaire (MS-TSQ) measures women's satisfaction with treatment for symptoms associated with menopause. The results of the development and initial validation are favorable for the use of the MS-TSQ with postmenopausal women who are receiving treatment for their menopausal symptoms.

From 1RTI Health Solutions Park, NC; and 2Wyeth Research, Research Triangle Collegeville, PA.

Received October 19, 2006; revised and accepted January 9, 2007.

Funding/support: Wyeth Research.

Financial disclosure: None reported.

Address correspondence to: Cheryl D. Hill, PhD, RTI Health Solutions, 200 Park Offices Drive, PO Box 12194, Research Triangle Park, NC 27709-2194. E-mail: cdhill@rti.org

©2007The North American Menopause Society