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Aromatase inhibitor therapy for uterine bleeding in a postmenopausal woman with leiomyomata

Kaunitz, Andrew M. MD

doi: 10.1097/gme.0b013e318054e2be
Case Report
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Although most women with symptoms caused by uterine fibroids are in their 30s or 40s, these tumors can cause postmenopausal bleeding. An obese postmenopausal woman experienced persistent uterine bleeding. Evaluation revealed no evidence of neoplasia, and the patient preferred medical to surgical management. Use of the aromatase inhibitor anastrozole was associated with reduction in the size of her dominant fibroid, thinning of her endometrium, and cessation of bleeding. If future studies confirm the promising findings observed in this patient, use of aromatase inhibitors may prove useful in treating uterine bleeding associated with fibroids in postmenopausal women.

In an obese postmenopausal woman with uterine bleeding associated with leiomyomata, use of the aromatase inhibitor anastrozole was associated with cessation of bleeding and a reduction in dominant fibroid dimensions.

From the Department of Obstetrics and Gynecology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL.

Received January 8, 2007; revised and accepted February 28, 2007.

Financial disclosure: None reported.

Reprints are not available.

Address correspondence to: Andrew M. Kaunitz, MD, Department of Obstetrics and Gynecology, University of Florida College of Medicine-Jacksonville, 653-1 W 8th Street, Jacksonville, FL 32209. E-mail: andrew.kaunitz@jax.ufl.edu

©2007The North American Menopause Society