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P84 Peutz-Jeghers syndrome-cutaneous manifestations-case report

Syrmos, N.; Isaakidis, P.; Tsirpanlis, V.; Paltatzidou, K.; Chatzinasiou, F.; Tzinas, S.

doi: 10.1097/01.cmr.0000382918.32026.c3
Malignant and other skin tumors

Department of Surgical, Naousa General Hospital, Naousa, Imathia, Macedonia, Greece

Peutz-Jeghers syndrome is an autosomal dominant disorder characterized by extensive hamartomatous polyps and carcinomas throughout the gastrointestinal tract, mainly the small intestine. Intussusception with resultant bleeding and abdominal pain is the most common gastrointestinal manifestation. The characteristic cutaneous features of this condition are the freckle-like pigmented macules that occur on the lips, nose, buccal mucosa, fingertips, and under the nails. The risk of gastrointestinal tumors is higher than in the general population, although most of these lesions do not evolve from the polyps, which are histologically benign. There appears to be an increased risk of pancreatic cancer, breast cancer, and reproductive neoplasms, including tumors of the cervix, ovary, and testis. Aim of this study is to present a case report of a 55 years man with Peutz-Jeghers syndrome.

© 2010 Lippincott Williams & Wilkins, Inc.