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P1 Primary multiple malignant tumors in skin melanomas in Ukraine

Korovin, S.; Kukushkina, M.

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doi: 10.1097/01.cmr.0000382833.82231.ef
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Introduction Skin melanoma is attributed to solid tumors but as many others oncologic diseases can be combined in different sequence with other primary tumors. The cases of coexistence in different sequence of two or more tumors that are the result of prevalebce (growth), relapsing or metastatic spreading are attributed to the true primary multiple malignant tumors. Aim. To study morbidity and course of primary multiple malignant tumors in skin melanoma.

Methods Sixteen thousand seven hundred and sixty cases of skin melanomas were diagnosed in Ukraine between 1998 and 2003. Primary multiple malignant tumor was registered in 873 patients of them. Polyneoplasias were distributed into synchronous ones (skin melanomas and other malignant tumor that were revealed for 12 months), type I metachronuos ones (primary manifestation of skin melanoma with following development of other malignant tumor at the term more than 12 months), type II metachronuos ones (skin melanoma diagnosed after manifestation of other malignant tumor with an interval more than 12 months) concerning the time of the manifestation for skin melanoma.

Results Polyneoplasia in skin melanoma is revealed in 5.2±0.1% cases among all melanoblastomas revealed in the Ukraine. The polyneoplasia occurrence in skin melanoma is fluctuated between 3.3 and 8.3% in different regions. Most frequent primary multiple malignant tumors are occurred in patients in skin melanoma of the head and the neck (6.6±0.4%). More frequent other skin malignant tumors (40.9±1.6% of all polyneoplasias) are accompanying skin melanoma. Multiple cancer is occurred more frequently in men (5.7±0.7%) with malignant skin melanoma comparing to women (4.9±0.7%). Most frequent skin melanoma is synchronically diagnosed in polyneoplasias (48.3±1.6%) there is the synchronous detection of primary multiple tumors prevailed over all polyneoplasias and in all age groups. Most favourable course of skin melanoma is characteristic for metachronous type II polyneoplasia when melanoma is diagnosed after manifestation of other malignant tumor. Five-year survival rate in synchronous polyneoplasia consisted of 36.1±2.3%, in type I metachronuos polyneoplasia −40.3±3.4%, and in type II metachronous polyneoplasia-61.8±3.0%).

Conclusion The peculiarities of morbidity, diagnosis and course of primary multiple malignant tumors in skin melanoma are required the further investigations.

© 2010 Lippincott Williams & Wilkins, Inc.