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FC5 Incidence and trends of cutaneous malignancies in The Netherlands, 1989–2005

Holterhues, C.a; de Vries, E.a b; Louwman, M.d; Koljenovic, S.c; Nijsten, T.a

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doi: 10.1097/01.cmr.0000382807.22204.dd
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Introduction Epidemiology of rare cutaneous malignancies in the general population is poorly documented. This descriptive study aimed to estimate the incidence and trends between 1989–2005 of all skin malignancies.

Methods Data on skin tumors were extracted from the Netherlands Cancer registry (except basal cell carcinoma (BCC) only available from Comprehensive Cancer Centre South) and categorized according to ICD-O3 codes. Age-standardized incidence rates (ESR) per 100,000 person-years were calculated per year and for the period 2001–2005. Estimated annual percentage changes (EAPC) were estimated by Poisson-regression models.

Results Between 1989–2005 356,620 skin tumors were diagnosed between 1989–2005. Excluding BCC, squamous cell carcinoma (SCC) and melanoma, the remaining skin tumors constituted about 2% of all skin malignancies. The incidence of melanoma increased steepest (EAPC 4.0%) and ESR was close to that observed for SCC (EAPC 2.3%) between 2001–2005 (17.1 vs. 19.6). Haematolymphoid tumors (ESR 0.74) were mainly cutaneous T-cell lymphomas (60.8%). No significant increases in incidence were observed for lymphomas, appendageal, fibromatous and myomatous carcinomas during 1989–2005.

Conclusion In addition to keratinocytic cancers and melanoma, there is wide variety of skin tumors that constitutes <2% of all skin malignancies. The incidence of UV related skin tumors increased significantly and more steeply than those of other skin malignancies.

© 2010 Lippincott Williams & Wilkins, Inc.