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FC4 Foods rich in polyphenols and N-3 fatty acids decrease cutaneous melanoma risk

Fortes, C.; Mastroeni, S.; Melchi, F.; Pilla, M.A.; Antonelli, G.; Camaioni, D.; Alotto, M.; Pasquini, P.

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doi: 10.1097/01.cmr.0000382806.14581.52
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Background Many studies have investigated the Mediterranean diet as a risk factor for cancer, none of which has included cutaneous melanoma. The latter is usually fatal, rendering knowledge about prevention extremely important. We assessed the role of some food components of the Mediterranean diet and cutaneous melanoma.

Methods A hospital-based case-control study was conducted in the inpatient wards of IDI-San Carlo Rome, Italy including 304 incident cases of cutaneous melanoma and 305 controls, frequency matched to cases. Information on socio-demographic characteristics, medical history, smoking, sun exposure, pigmentary characteristics anddiet was collected. Logistic regression was the method used to estimated odds ratio and 95% confidence intervals.

Results After careful control for several sun exposure and pigmentary characteristics, we found a protective effect for weekly consumption of fish (OR, 0.65, 95% CI=0.43–0.97), shellfish (OR, 0.53, 95% CI=0.31–0.89), fish rich in n-3 fatty acids (OR, 0.52, 95% CI=0.34–0.78), daily tea drinking (OR, 0.42, 95% CI, 0.18–0.95; P trend=0.025), and high consumption of vegetables (OR, 0.50, 95% CI=0.31–0.80, P trend=0.005) in particular carrots, cruciferous and leafy vegetables and fruits (OR, 0.54, 95% CI, 0.33–0.86 P trend=0.013), in particular citrus fruits. No association was found for alcohol consumption and any other food items.

Conclusion Our findings support evidence linking some foods rich in polyphenols and N-3 fatty acids to decrease cutaneous melanoma risk and suggest that these foods may be indicators of the protective effect of the Mediterranean diet.

© 2010 Lippincott Williams & Wilkins, Inc.