Short CommunicationPreoperative assessment of cutaneous melanoma thickness by multispectral dermoscopyJanssen, Laudinea; Van Kelst, Sofiea; De Smedt, Juliea; Terrasson, Juliea; Diricx, Bartb; Kimpe, Tomb; Papeleu, Jorienc; Verhaeghe, Evelienc; Brochez, Lievec; Garmyn, Marjana Author Information aDepartment of Dermatology, KU Leuven, Leuven bBarco NV, healthcare, Kortrijk cDepartment of Dermatology, UZ Gent, Gent, Belgium Received 19 May 2022 Accepted 10 September 2022 Correspondence to Marjan Garmyn, MD, PhD, Department of Dermatology, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium, Tel: +32 16 337950; e-mail: [email protected] Melanoma Research 33(1):p 84-86, February 2023. | DOI: 10.1097/CMR.0000000000000862 Buy Metrics Abstract Preoperative assessment of Breslow thickness by means of sonography and clinical and dermoscopic criteria in white light dermoscopy has been reported, but up until now, the use of multispectral dermoscopy has not been investigated. Aim of this research is to determine whether multispectral dermoscopy and more specifically pigment maps can be used as a predictive marker for Breslow thickness in melanoma. Pigment maps are generated in real time from multispectral dermoscopic images and help to visualize the presence of pigment in a lesion. Multispectral images of 110 melanomas were collected, using a digital handheld multispectral dermatoscope, and assessed independently by five observers for the presence or absence of deep pigment compared with the surrounding skin. According to histopathological examination, the mean Breslow thickness of all 110 melanomas was 1.04 mm (ranging from 0.1 to 14 mm). The group of melanomas where deep pigment was visualized on the multispectral image (n = 78) had a significantly higher Breslow thickness (1.19 mm) than the group where no deep pigment was observed (n = 32, mean Breslow 0.68 mm) (P = 0.025). This study is unique in preoperative assessment of tumour thickness by means of multispectral dermoscopy. Our data indicate that the presence of deep pigment as visualized in digital dermoscopic skin parameter maps identifies a group of thicker melanomas. Further prospective research is needed to validate these pigment maps, generated by multispectral dermoscopy as a measure to predict invasiveness in melanoma. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.