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Melanoma Explorer

a web application to allow easy reanalysis of publicly available and clinically annotated melanoma omics data sets

Strbenac, Darioa; Wang, Kevina; Wang, Xinyuea,d; Dong, Jiamina; Mann, Graham J.b,c; Mueller, Samuela; Yang, Jean Y.H.a

doi: 10.1097/CMR.0000000000000533
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Validating newly discovered biomarkers in large, publicly available data sets is often difficult and requires specialized computer programming skills. Melanoma Explorer is a web application that enables easy interrogation of melanoma omics data sets that are freely available in online data repositories with a point-and-click interface. Two use cases are demonstrated. First, the relationship of lysozyme mRNA expression is shown to be prognostic in two independent gene expression microarray data sets. Second, a figure from a journal article showing the relationship of tumour thickness and miR-382 abundance is reproduced. Melanoma Explorer is demonstrated to be a useful tool for reproducing results of published studies and providing additional evidence for biomarkers in independent data sets.

aSchool of Mathematics and Statistics

bCentre for Cancer Research, Westmead Institute for Medical Research

cMelanoma Institute Australia, University of Sydney

dData61, CSIRO, Sydney, NSW, Australia

Correspondence to Jean Y.H. Yang, PhD, School of Mathematics and Statistics, Carslaw Building, City Road Camperdown, NSW 2006, Australia Tel/fax: +61 293 514 534; e-mail: jean.yang@sydney.edu.au

Received July 24, 2018

Accepted October 3, 2018

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