Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Inositol hexaphosphate plus inositol induced complete remission in stage IV melanoma

a case report

Khurana, Sharad; Baldeo, Candice; Joseph, Richard W.

doi: 10.1097/CMR.0000000000000577

Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. It has been shown to inhibit the growth of many different tumor cell lines both in vitro and in vivo like colon, pancreas, liver, prostate, and even melanoma. Vitamin B inositol is a precursor of IP6 and another naturally occurring compound with anticancer properties. We present a case report of a patient with metastatic melanoma who declined traditional therapy and opted to try over the counter supplement IP6+inositol instead. To our surprise, the patient achieved a complete remission and remains in remission 3 years later. On the basis of this case and previous preclinical studies, we believe further research is indicated in exploring antiproliferative and potential immune stimulating effects of IP6+inositol in patients with metastatic melanoma.

Department of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida, USA

Correspondence to Sharad Khurana, MD, Department of Hematology/Oncology, 4500 San Pablo Road, Mangurian Building, Jacksonville, FL 32224, USA Tel: +1 904 953 2000; fax: +1 904 953 2315; e-mail:

Received October 29, 2018

Accepted December 26, 2018

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.