SHORT COMMUNICATIONSFascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanomaMa, Yafenga,e; Faller, William J.a; Sansom, Owen J.a; Brown, Ewan R.b; Doig, Tamasin N.c; Melton, David W.d; Machesky, Laura M.aAuthor Information aBeatson Institute for Cancer Research, Glasgow bEdinburgh Cancer Centre cDepartment of Pathology, NHS Lothian, Western General Hospital dEdinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK eMedical Oncology Group, Ingham Institute for Applied Medical Research, School of Medicine, University of New South Wales, New South Wales, Australia Correspondence to Laura M. Machesky, PhD, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD Scotland, UK Tel: +44 1413303653; fax: +44 141 9426521; e-mail: [email protected] Received June 16, 2014 Accepted November 10, 2014 Melanoma Research: April 2015 - Volume 25 - Issue 2 - p 169-172 doi: 10.1097/CMR.0000000000000135 Buy Metrics Abstract Levels of the actin bundling protein fascin correlate with invasion and metastasis and reveal prognostic value in many epithelial carcinomas. However, we know very little about the potential role of fascin in melanoma. The purpose of this study is to compare fascin expression in primary melanomas and melanoma metastasis. Fascin expression was examined through the immunohistochemistry of paraffin embedded tissue microarrays including 560 cores of primary tumour and metastasis. Fascin expression was significantly elevated in 48 metastases compared with 254 primary tumours (P=0.034). In 187 patients with primary melanomas, fascin was not correlated with survival (P=0.067), whereas low fascin was significantly correlated with the presence of ulceration (P=0.005). Our results indicate that fascin status does not correlate with progression in melanoma. Upregulated fascin expression was detected in melanoma metastases, but was not correlated to patient outcome. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.