ORIGINAL ARTICLES: Clinical researchDynamic contrast-enhanced MRI of ocular melanomaJiang, Xuyuana; Asbach, Patrickb; Willerding, Gregorc; Dulce, Miriamb; Xu, Kea; Taupitz, Matthiasb; Hamm, Berndb; Erb-Eigner, KatharinabAuthor Information aDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China bDepartment of Radiology, Charité – Universitätsmedizin Berlin cDepartment of Ophthalmology, DRK Kliniken Westend, Berlin, Germany All supplementary data is available directly from the corresponding author. Correspondence to Ke Xu, MD, Department of Radiology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, 110001 Shenyang, China Tel: +86 24 8328 2999; fax: +86 24 8328 2997; e-mail: [email protected] and Katharina Erb-Eigner, MD, Department of Radiology, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany Tel: +49 30 8445 3041; fax: +49 30 450 7527953; e-mail: [email protected] Received December 5, 2014 Accepted December 23, 2014 Melanoma Research: April 2015 - Volume 25 - Issue 2 - p 149-156 doi: 10.1097/CMR.0000000000000142 Buy Metrics Abstract Dynamic contrast-enhanced MRI is used for the assessment of microvasculature in several tumours. We aimed to assess the contrast signal enhancement characteristics of ocular melanoma. Forty patients with ocular melanoma were prospectively investigated with ocular MRI including dynamic contrast-enhanced sequences over a 13-month period. A region-of-interest analysis of the images was carried out to calculate signal enhancement characteristics after a contrast injection. Clinical follow-up data such as extraocular spread and development of liver metastasis were compared with the signal enhancement characteristics of the ocular melanoma. In 39 patients (98%), the ocular melanomas showed an early strong signal enhancement after contrast injection, resulting in a mean time of maximum enhancement of 49 s. Clinical follow-up was available in 28 patients (70%) and indicated that the peak signal intensity was significantly increased (P=0.039) in patients who developed extraocular spread or liver metastasis at a later stage. Ocular melanoma shows signal enhancement characteristics of hypervascular neoplasms. This study provides baseline curve pattern data that may be useful for assessing changes in vascularity, for example during therapy response. Furthermore, the study showed that a strong signal enhancement of the ocular melanoma might be linked to a less favourable prognosis. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.