REVIEW ARTICLESSpontaneous regression of transplacental metastases from maternal melanoma in a newborn: case report and review of the literatureValenzano Menada, Marioa; Moioli, Melitaa e; Garaventa, Albertoc; Nozza, Paolod; Foppiano, Marilenaa; Trimarchi, Nadiab; Fulcheri, EziobAuthor Information Departments of aObstetrics and Gynecology bAnatomic Pathology, San Martino Hospital, University of Genoa Departments of cOncology dAnatomic Pathology, Giannina Gaslini Institute, Genoa eDepartment of Obstetrics and Gynecology, San Gerar do Hospital, University of Milan Bicocca, Monza, Italy Correspondence to Dr Melita Moioli, MD, Department of Obstetrics and Gynecology, San Gerardo Hospital, University of Milan Bicocca, Via Pergolesi 33, Monza, Italy Tel: +39 039 2339434; fax: +39 039 2339229; e-mail: [email protected] Received 27 April 2010 Accepted 15 August 2010 Melanoma Research: December 2010 - Volume 20 - Issue 6 - p 443-449 doi: 10.1097/CMR.0b013e32833faf6a Buy Metrics Abstract We describe a rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman. She was aware of a greyish–brown nodular lesion on the right gluteus during her first pregnancy. On histological examination, this lesion resulted to be an amelanocitic melanoma. Breast metastases occurred during her second pregnancy, 18 months after the surgical excision; an emergency Caesarean section performed for the recrudement of her clinical conditions confirmed widespread metastases to the liver, spleen and peritoneum. The patient died 2 weeks after delivery. The newborn, at 3 months of age, presented metastases secondary to maternal melanoma, which were resistant to chemotherapy. The disease regressed spontaneously and the child is now 24 months, alive in complete remission. © 2010 Lippincott Williams & Wilkins, Inc.